HCSGD entry for NEDD4
1. General information
| Official gene symbol | NEDD4 |
|---|---|
| Entrez ID | 4734 |
| Gene full name | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase |
| Other gene symbols | NEDD4-1 RPF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | ISS | cellular_component |
| GO:0000785 | Chromatin | IDA | cellular_component |
| GO:0002250 | Adaptive immune response | IEA | biological_process |
| GO:0003151 | Outflow tract morphogenesis | IEA | biological_process |
| GO:0003197 | Endocardial cushion development | IEA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | ISS TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA IMP | cellular_component |
| GO:0005938 | Cell cortex | IDA | cellular_component |
| GO:0006513 | Protein monoubiquitination | IEA | biological_process |
| GO:0006622 | Protein targeting to lysosome | IDA | biological_process |
| GO:0007041 | Lysosomal transport | IDA | biological_process |
| GO:0007528 | Neuromuscular junction development | IEA | biological_process |
| GO:0010766 | Negative regulation of sodium ion transport | IDA | biological_process |
| GO:0010768 | Negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage | IMP | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | IMP | biological_process |
| GO:0016327 | Apicolateral plasma membrane | TAS | cellular_component |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0019089 | Transmission of virus | IMP | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019871 | Sodium channel inhibitor activity | IDA | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030948 | Negative regulation of vascular endothelial growth factor receptor signaling pathway | ISS | biological_process |
| GO:0031175 | Neuron projection development | IEP | biological_process |
| GO:0031623 | Receptor internalization | IDA | biological_process |
| GO:0031698 | Beta-2 adrenergic receptor binding | IDA | molecular_function |
| GO:0032801 | Receptor catabolic process | IDA | biological_process |
| GO:0034644 | Cellular response to UV | IMP | biological_process |
| GO:0034765 | Regulation of ion transmembrane transport | IDA | biological_process |
| GO:0042110 | T cell activation | IEA | biological_process |
| GO:0042391 | Regulation of membrane potential | IDA | biological_process |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA IMP | biological_process |
| GO:0042921 | Glucocorticoid receptor signaling pathway | IDA | biological_process |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0043162 | Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | IMP | biological_process |
| GO:0044111 | Development involved in symbiotic interaction | IMP | biological_process |
| GO:0045732 | Positive regulation of protein catabolic process | IDA | biological_process |
| GO:0046824 | Positive regulation of nucleocytoplasmic transport | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0048514 | Blood vessel morphogenesis | IEA | biological_process |
| GO:0048814 | Regulation of dendrite morphogenesis | ISS | biological_process |
| GO:0050807 | Regulation of synapse organization | IEA | biological_process |
| GO:0050815 | Phosphoserine binding | ISS | molecular_function |
| GO:0050816 | Phosphothreonine binding | ISS | molecular_function |
| GO:0050847 | Progesterone receptor signaling pathway | IDA | biological_process |
| GO:0051592 | Response to calcium ion | TAS | biological_process |
| GO:0070063 | RNA polymerase binding | IPI | molecular_function |
| GO:0070064 | Proline-rich region binding | IMP IPI | molecular_function |
| GO:0070534 | Protein K63-linked ubiquitination | ISS | biological_process |
| GO:1901016 | Regulation of potassium ion transmembrane transporter activity | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1375917746 | 0.1048826754 | 0.7473283326 | 0.6208296829 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0851713347 |
| GSE13712_SHEAR | Up | 0.2266211865 |
| GSE13712_STATIC | Up | 0.2347011829 |
| GSE19018 | Up | 0.9256090032 |
| GSE19899_A1 | Down | -0.6465942519 |
| GSE19899_A2 | Down | -0.1685049846 |
| PubMed_21979375_A1 | Up | 0.7321619647 |
| PubMed_21979375_A2 | Up | 0.1376639957 |
| GSE35957 | Up | 0.3260452874 |
| GSE36640 | Up | 0.6180787424 |
| GSE54402 | Down | -0.5442595514 |
| GSE9593 | Down | -0.1488877408 |
| GSE43922 | Down | -0.3483595186 |
| GSE24585 | Up | 0.1602809214 |
| GSE37065 | Up | 0.0448403342 |
| GSE28863_A1 | Down | -0.5076520047 |
| GSE28863_A2 | Down | -0.0531458233 |
| GSE28863_A3 | Down | -0.7674829036 |
| GSE28863_A4 | Up | 0.0969980788 |
| GSE48662 | Down | -0.1885606577 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001612 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT007131 | qRT-PCR | Functional MTI (Weak) | 23418453 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016194 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022426 | Microarray | Functional MTI (Weak) | 18668037 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23549616 | Upregulation of SIRT1 by 17beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1 |
| 23549616 | The PPARgamma interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif |
| 23549616 | The WW3 domain in NEDD4-1 is critical for binding to PPARGamma |
| 23549616 | NEDD4-1 overexpression leads to PPARgamma ubiquitination and reduced expression of PPARgamma |
| 23549616 | Conversely, knockdown of NEDD4-1 by specific siRNAs abolishes PPARGamma ubiquitination |
Entries Per Page
Displaying Page of
