HCSGD entry for NEDD4

1. General information

Official gene symbolNEDD4
Entrez ID4734
Gene full nameneural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Other gene symbolsNEDD4-1 RPF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexISScellular_component
GO:0000785ChromatinIDAcellular_component
GO:0002250Adaptive immune responseIEAbiological_process
GO:0003151Outflow tract morphogenesisIEAbiological_process
GO:0003197Endocardial cushion developmentIEAbiological_process
GO:0004842Ubiquitin-protein ligase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIBAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolISS TAScellular_component
GO:0005886Plasma membraneIDA IMPcellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0006513Protein monoubiquitinationIEAbiological_process
GO:0006622Protein targeting to lysosomeIDAbiological_process
GO:0007041Lysosomal transportIDAbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0010766Negative regulation of sodium ion transportIDAbiological_process
GO:0010768Negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damageIMPbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIMPbiological_process
GO:0016327Apicolateral plasma membraneTAScellular_component
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0019089Transmission of virusIMPbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019871Sodium channel inhibitor activityIDAmolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030948Negative regulation of vascular endothelial growth factor receptor signaling pathwayISSbiological_process
GO:0031175Neuron projection developmentIEPbiological_process
GO:0031623Receptor internalizationIDAbiological_process
GO:0031698Beta-2 adrenergic receptor bindingIDAmolecular_function
GO:0032801Receptor catabolic processIDAbiological_process
GO:0034644Cellular response to UVIMPbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0042391Regulation of membrane potentialIDAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDA IMPbiological_process
GO:0042921Glucocorticoid receptor signaling pathwayIDAbiological_process
GO:0043130Ubiquitin bindingIDAmolecular_function
GO:0043162Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayIMPbiological_process
GO:0044111Development involved in symbiotic interactionIMPbiological_process
GO:0045732Positive regulation of protein catabolic processIDAbiological_process
GO:0046824Positive regulation of nucleocytoplasmic transportIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048514Blood vessel morphogenesisIEAbiological_process
GO:0048814Regulation of dendrite morphogenesisISSbiological_process
GO:0050807Regulation of synapse organizationIEAbiological_process
GO:0050815Phosphoserine bindingISSmolecular_function
GO:0050816Phosphothreonine bindingISSmolecular_function
GO:0050847Progesterone receptor signaling pathwayIDAbiological_process
GO:0051592Response to calcium ionTASbiological_process
GO:0070063RNA polymerase bindingIPImolecular_function
GO:0070064Proline-rich region bindingIMP IPImolecular_function
GO:0070534Protein K63-linked ubiquitinationISSbiological_process
GO:1901016Regulation of potassium ion transmembrane transporter activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13759177460.10488267540.74732833260.6208296829

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0851713347
GSE13712_SHEARUp0.2266211865
GSE13712_STATICUp0.2347011829
GSE19018Up0.9256090032
GSE19899_A1Down-0.6465942519
GSE19899_A2Down-0.1685049846
PubMed_21979375_A1Up0.7321619647
PubMed_21979375_A2Up0.1376639957
GSE35957Up0.3260452874
GSE36640Up0.6180787424
GSE54402Down-0.5442595514
GSE9593Down-0.1488877408
GSE43922Down-0.3483595186
GSE24585Up0.1602809214
GSE37065Up0.0448403342
GSE28863_A1Down-0.5076520047
GSE28863_A2Down-0.0531458233
GSE28863_A3Down-0.7674829036
GSE28863_A4Up0.0969980788
GSE48662Down-0.1885606577

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT001612pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-30c-5pMIMAT0000244MIRT007131qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-590-3pMIMAT0004801MIRT016194SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022426MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23549616Upregulation of SIRT1 by 17beta-estradiol depends on ubiquitin-proteasome degradation of PPAR-gamma mediated by NEDD4-1
23549616The PPARgamma interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif
23549616The WW3 domain in NEDD4-1 is critical for binding to PPARGamma
23549616NEDD4-1 overexpression leads to PPARgamma ubiquitination and reduced expression of PPARgamma
23549616Conversely, knockdown of NEDD4-1 by specific siRNAs abolishes PPARGamma ubiquitination
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