HCSGD entry for NDUFS2
1. General information
| Official gene symbol | NDUFS2 |
|---|---|
| Entrez ID | 4720 |
| Gene full name | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) |
| Other gene symbols | CI-49 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003954 | NADH dehydrogenase activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA NAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005747 | Mitochondrial respiratory chain complex I | IDA IMP NAS | cellular_component |
| GO:0006120 | Mitochondrial electron transport, NADH to ubiquinone | NAS | biological_process |
| GO:0006979 | Response to oxidative stress | IDA | biological_process |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | NAS | molecular_function |
| GO:0009055 | Electron carrier activity | NAS | molecular_function |
| GO:0016651 | Oxidoreductase activity, acting on NAD(P)H | IEA | molecular_function |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048038 | Quinone binding | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4877628092 | 0.5287154971 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3899987408 |
| GSE13712_SHEAR | Up | 0.1512352667 |
| GSE13712_STATIC | Up | 0.0776945741 |
| GSE19018 | Up | 0.3857448899 |
| GSE19899_A1 | Up | 0.4204308037 |
| GSE19899_A2 | Up | 0.0861772359 |
| PubMed_21979375_A1 | Up | 0.0082432410 |
| PubMed_21979375_A2 | Down | -0.0689786565 |
| GSE35957 | Down | -0.3059513896 |
| GSE36640 | Down | -0.0498328942 |
| GSE54402 | Up | 0.2376003989 |
| GSE9593 | Down | -0.2660684118 |
| GSE43922 | Down | -0.0105906016 |
| GSE24585 | Down | -0.1049797100 |
| GSE37065 | Down | -0.0808686341 |
| GSE28863_A1 | Down | -0.0354063983 |
| GSE28863_A2 | Down | -0.1025028227 |
| GSE28863_A3 | Down | -0.3714420291 |
| GSE28863_A4 | Down | -0.1886127699 |
| GSE48662 | Up | 0.0013148104 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-940 | MIMAT0004983 | MIRT036624 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052485 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
