HCSGD entry for NDUFS2


1. General information

Official gene symbolNDUFS2
Entrez ID4720
Gene full nameNADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Other gene symbolsCI-49
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003954NADH dehydrogenase activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIDA NAScellular_component
GO:0005743Mitochondrial inner membraneTAScellular_component
GO:0005747Mitochondrial respiratory chain complex IIDA IMP NAScellular_component
GO:0006120Mitochondrial electron transport, NADH to ubiquinoneNASbiological_process
GO:0006979Response to oxidative stressIDAbiological_process
GO:0008137NADH dehydrogenase (ubiquinone) activityNASmolecular_function
GO:0009055Electron carrier activityNASmolecular_function
GO:0016651Oxidoreductase activity, acting on NAD(P)HIEAmolecular_function
GO:0022904Respiratory electron transport chainTASbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048038Quinone bindingIEAmolecular_function
GO:0051287NAD bindingIEAmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48776280920.52871549710.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3899987408
GSE13712_SHEARUp0.1512352667
GSE13712_STATICUp0.0776945741
GSE19018Up0.3857448899
GSE19899_A1Up0.4204308037
GSE19899_A2Up0.0861772359
PubMed_21979375_A1Up0.0082432410
PubMed_21979375_A2Down-0.0689786565
GSE35957Down-0.3059513896
GSE36640Down-0.0498328942
GSE54402Up0.2376003989
GSE9593Down-0.2660684118
GSE43922Down-0.0105906016
GSE24585Down-0.1049797100
GSE37065Down-0.0808686341
GSE28863_A1Down-0.0354063983
GSE28863_A2Down-0.1025028227
GSE28863_A3Down-0.3714420291
GSE28863_A4Down-0.1886127699
GSE48662Up0.0013148104

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-940MIMAT0004983MIRT036624CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052485CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.