HCSGD entry for NCK1

1. General information

Official gene symbolNCK1
Entrez ID4690
Gene full nameNCK adaptor protein 1
Other gene symbolsNCK NCKalpha nck-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004860Protein kinase inhibitor activityIDAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmNAScellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006417Regulation of translationIEAbiological_process
GO:0006469Negative regulation of protein kinase activityIDAbiological_process
GO:0007015Actin filament organizationIEAbiological_process
GO:0007172Signal complex assemblyNASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008093Cytoskeletal adaptor activityNASmolecular_function
GO:0012506Vesicle membraneIEAcellular_component
GO:0016477Cell migrationIEAbiological_process
GO:0019887Protein kinase regulator activityIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030032Lamellipodium assemblyIEAbiological_process
GO:0030159Receptor signaling complex scaffold activityNASmolecular_function
GO:0030838Positive regulation of actin filament polymerizationIEA IMPbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042102Positive regulation of T cell proliferationIMPbiological_process
GO:0042110T cell activationIMPbiological_process
GO:0042325Regulation of phosphorylationIDAbiological_process
GO:0042326Negative regulation of phosphorylationIDAbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051707Response to other organismIEAbiological_process
GO:0060548Negative regulation of cell deathIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30431160290.41543828880.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2720804882
GSE13712_SHEARDown-0.0907812142
GSE13712_STATICUp0.1889921092
GSE19018Up0.0875278623
GSE19899_A1Up0.0488046799
GSE19899_A2Up0.1510572196
PubMed_21979375_A1Up0.1644472533
PubMed_21979375_A2Down-0.1352823888
GSE35957Down-0.1802583781
GSE36640Up0.3633002595
GSE54402Down-0.2910101436
GSE9593Up0.5118053896
GSE43922Up0.0058392509
GSE24585Up0.2129863688
GSE37065Up0.2979861164
GSE28863_A1Up0.2774183109
GSE28863_A2Up0.1656396277
GSE28863_A3Down-0.7228844490
GSE28863_A4Down-0.3215389482
GSE48662Down-0.3352687327

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.