HCSGD entry for NCK1

1. General information

Official gene symbolNCK1
Entrez ID4690
Gene full nameNCK adaptor protein 1
Other gene symbolsNCK NCKalpha nck-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004860Protein kinase inhibitor activityIDAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmNAScellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006417Regulation of translationIEAbiological_process
GO:0006469Negative regulation of protein kinase activityIDAbiological_process
GO:0007015Actin filament organizationIEAbiological_process
GO:0007172Signal complex assemblyNASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008093Cytoskeletal adaptor activityNASmolecular_function
GO:0012506Vesicle membraneIEAcellular_component
GO:0016477Cell migrationIEAbiological_process
GO:0019887Protein kinase regulator activityIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030032Lamellipodium assemblyIEAbiological_process
GO:0030159Receptor signaling complex scaffold activityNASmolecular_function
GO:0030838Positive regulation of actin filament polymerizationIEA IMPbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042102Positive regulation of T cell proliferationIMPbiological_process
GO:0042110T cell activationIMPbiological_process
GO:0042325Regulation of phosphorylationIDAbiological_process
GO:0042326Negative regulation of phosphorylationIDAbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051707Response to other organismIEAbiological_process
GO:0060548Negative regulation of cell deathIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30431160290.41543828880.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2720804882
GSE13712_SHEARDown-0.0907812142
GSE13712_STATICUp0.1889921092
GSE19018Up0.0875278623
GSE19899_A1Up0.0488046799
GSE19899_A2Up0.1510572196
PubMed_21979375_A1Up0.1644472533
PubMed_21979375_A2Down-0.1352823888
GSE35957Down-0.1802583781
GSE36640Up0.3633002595
GSE54402Down-0.2910101436
GSE9593Up0.5118053896
GSE43922Up0.0058392509
GSE24585Up0.2129863688
GSE37065Up0.2979861164
GSE28863_A1Up0.2774183109
GSE28863_A2Up0.1656396277
GSE28863_A3Down-0.7228844490
GSE28863_A4Down-0.3215389482
GSE48662Down-0.3352687327

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.