HCSGD entry for MYLK
1. General information
| Official gene symbol | MYLK |
|---|---|
| Entrez ID | 4638 |
| Gene full name | myosin light chain kinase |
| Other gene symbols | AAT7 KRP MLCK MLCK1 MLCK108 MLCK210 MSTP083 MYLK1 smMLCK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001725 | Stress fiber | IDA | cellular_component |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004687 | Myosin light chain kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0006939 | Smooth muscle contraction | ISS | biological_process |
| GO:0014820 | Tonic smooth muscle contraction | ISS | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030335 | Positive regulation of cell migration | IDA | biological_process |
| GO:0032060 | Bleb assembly | IMP | biological_process |
| GO:0032154 | Cleavage furrow | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051928 | Positive regulation of calcium ion transport | IDA | biological_process |
| GO:0060414 | Aorta smooth muscle tissue morphogenesis | IMP | biological_process |
| GO:0071476 | Cellular hypotonic response | IDA | biological_process |
| GO:0090303 | Positive regulation of wound healing | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7244669655 | 0.0045253562 | 0.9999902473 | 0.1359724886 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8445393295 |
| GSE13712_SHEAR | Up | 0.2457441461 |
| GSE13712_STATIC | Down | -0.0186399491 |
| GSE19018 | Down | -0.8569975885 |
| GSE19899_A1 | Down | -1.0130073230 |
| GSE19899_A2 | Down | -1.2142951237 |
| PubMed_21979375_A1 | Down | -1.5174461103 |
| PubMed_21979375_A2 | Down | -0.9005382526 |
| GSE35957 | Up | 0.1961762599 |
| GSE36640 | Up | 0.2755763547 |
| GSE54402 | Down | -0.6158244292 |
| GSE9593 | Up | 0.4600540137 |
| GSE43922 | Down | -1.2442451661 |
| GSE24585 | Up | 0.2283519751 |
| GSE37065 | Down | -0.4738494317 |
| GSE28863_A1 | Up | 0.2598515063 |
| GSE28863_A2 | Up | 0.6543417716 |
| GSE28863_A3 | Down | -0.5248776734 |
| GSE28863_A4 | Down | -0.1685062840 |
| GSE48662 | Up | 0.1145335643 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016318 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021378 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
