HCSGD entry for MYLK

1. General information

Official gene symbolMYLK
Entrez ID4638
Gene full namemyosin light chain kinase
Other gene symbolsAAT7 KRP MLCK MLCK1 MLCK108 MLCK210 MSTP083 MYLK1 smMLCK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001725Stress fiberIDAcellular_component
GO:0003779Actin bindingIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004687Myosin light chain kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006936Muscle contractionTASbiological_process
GO:0006939Smooth muscle contractionISSbiological_process
GO:0014820Tonic smooth muscle contractionISSbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0030027LamellipodiumIDAcellular_component
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0032060Bleb assemblyIMPbiological_process
GO:0032154Cleavage furrowIDAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
GO:0060414Aorta smooth muscle tissue morphogenesisIMPbiological_process
GO:0071476Cellular hypotonic responseIDAbiological_process
GO:0090303Positive regulation of wound healingIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72446696550.00452535620.99999024730.1359724886

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8445393295
GSE13712_SHEARUp0.2457441461
GSE13712_STATICDown-0.0186399491
GSE19018Down-0.8569975885
GSE19899_A1Down-1.0130073230
GSE19899_A2Down-1.2142951237
PubMed_21979375_A1Down-1.5174461103
PubMed_21979375_A2Down-0.9005382526
GSE35957Up0.1961762599
GSE36640Up0.2755763547
GSE54402Down-0.6158244292
GSE9593Up0.4600540137
GSE43922Down-1.2442451661
GSE24585Up0.2283519751
GSE37065Down-0.4738494317
GSE28863_A1Up0.2598515063
GSE28863_A2Up0.6543417716
GSE28863_A3Down-0.5248776734
GSE28863_A4Down-0.1685062840
GSE48662Up0.1145335643

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016318MicroarrayFunctional MTI (Weak)20304954
hsa-miR-9-5pMIMAT0000441MIRT021378MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.