HCSGD entry for MUC1

1. General information

Official gene symbolMUC1
Entrez ID4582
Gene full namemucin 1, cell surface associated
Other gene symbolsCA 15-3 CD227 EMA H23AG KL-6 MAM6 MUC-1 MUC-1/SEC MUC-1/X MUC1/ZD PEM PEMT PUM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDAcellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001666Response to hypoxiaIEAbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0003712Transcription cofactor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005737CytoplasmIBA IEAcellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0009986Cell surfaceIBA IEAcellular_component
GO:0010944Negative regulation of transcription by competitive promoter bindingIDAbiological_process
GO:0016266O-glycan processingTASbiological_process
GO:0016324Apical plasma membraneIBA IEAcellular_component
GO:0030855Epithelial cell differentiationIEAbiological_process
GO:0036003Positive regulation of transcription from RNA polymerase II promoter in response to stressIDAbiological_process
GO:0043618Regulation of transcription from RNA polymerase II promoter in response to stressIDAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0090240Positive regulation of histone H4 acetylationIDAbiological_process
GO:1902166Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17535776380.31201254510.82255933711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5226878303
GSE13712_SHEARDown-0.0523751020
GSE13712_STATICUp0.1364114986
GSE19018Up0.0806257842
GSE19899_A1Up0.0704128009
GSE19899_A2Down-0.4365293226
PubMed_21979375_A1Down-0.1480090215
PubMed_21979375_A2Down-0.0452108053
GSE35957Up0.5995100720
GSE36640Up0.2433188655
GSE54402Down-1.5384449884
GSE9593Up0.3723352555
GSE43922Down-0.0629040615
GSE24585Up0.5097493307
GSE37065Down-0.0294647643
GSE28863_A1Up0.1866946055
GSE28863_A2Up0.4829765169
GSE28863_A3Up0.3411094766
GSE28863_A4Down-0.0752149570
GSE48662Up0.0874558489

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT000426Luciferase reporter assay//Western blotFunctional MTI20407606
hsa-miR-145-5pMIMAT0000437MIRT000426Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot//Reporter assayFunctional MTI19996288
hsa-miR-1226-3pMIMAT0005577MIRT005492Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI20514397
hsa-miR-335-5pMIMAT0000765MIRT017760MicroarrayFunctional MTI (Weak)18185580
hsa-miR-125b-5pMIMAT0000423MIRT022114Reporter assay;Western blotFunctional MTI20729973
hsa-miR-124-3pMIMAT0000422MIRT022593Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT030810MicroarrayFunctional MTI (Weak)18591254
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-145-5pMIMAT00004371hsa-miR-145{Western blot}{overexpression}19996288
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25964555MATERIALS AND METHODS: Multiplex Ligation-dependent Probe Amplification, TP53 sequencing, real-time polymerase chain reaction (PCR) for MUC1 and SCGB2A2 and immunocytochemistry, together with senescence detection assay and real-time microscopic observations were used to analyze primary neoplastic cells isolated from prostate, breast and colorectal tumors, as well as stable cancer cell lines (MCF7, MDA-MB-468, SW962, SK-MEL28, NCI-H1975 and NCI-H469)
19751512Analysis of surface markers during long term tumor culture of primary HBCEC (more than 476d) demonstrated a prominent expression of CD24, CD44 and MUC1 (CD227)
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