HCSGD entry for MUC1

1. General information

Official gene symbolMUC1
Entrez ID4582
Gene full namemucin 1, cell surface associated
Other gene symbolsCA 15-3 CD227 EMA H23AG KL-6 MAM6 MUC-1 MUC-1/SEC MUC-1/X MUC1/ZD PEM PEMT PUM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDAcellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001666Response to hypoxiaIEAbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0003712Transcription cofactor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005737CytoplasmIBA IEAcellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIDAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0009986Cell surfaceIBA IEAcellular_component
GO:0010944Negative regulation of transcription by competitive promoter bindingIDAbiological_process
GO:0016266O-glycan processingTASbiological_process
GO:0016324Apical plasma membraneIBA IEAcellular_component
GO:0030855Epithelial cell differentiationIEAbiological_process
GO:0036003Positive regulation of transcription from RNA polymerase II promoter in response to stressIDAbiological_process
GO:0043618Regulation of transcription from RNA polymerase II promoter in response to stressIDAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0090240Positive regulation of histone H4 acetylationIDAbiological_process
GO:1902166Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17535776380.31201254510.82255933711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5226878303
GSE13712_SHEARDown-0.0523751020
GSE13712_STATICUp0.1364114986
GSE19018Up0.0806257842
GSE19899_A1Up0.0704128009
GSE19899_A2Down-0.4365293226
PubMed_21979375_A1Down-0.1480090215
PubMed_21979375_A2Down-0.0452108053
GSE35957Up0.5995100720
GSE36640Up0.2433188655
GSE54402Down-1.5384449884
GSE9593Up0.3723352555
GSE43922Down-0.0629040615
GSE24585Up0.5097493307
GSE37065Down-0.0294647643
GSE28863_A1Up0.1866946055
GSE28863_A2Up0.4829765169
GSE28863_A3Up0.3411094766
GSE28863_A4Down-0.0752149570
GSE48662Up0.0874558489

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT000426Luciferase reporter assay//Western blotFunctional MTI20407606
hsa-miR-145-5pMIMAT0000437MIRT000426Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot//Reporter assayFunctional MTI19996288
hsa-miR-1226-3pMIMAT0005577MIRT005492Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI20514397
hsa-miR-335-5pMIMAT0000765MIRT017760MicroarrayFunctional MTI (Weak)18185580
hsa-miR-125b-5pMIMAT0000423MIRT022114Reporter assay;Western blotFunctional MTI20729973
hsa-miR-124-3pMIMAT0000422MIRT022593Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT030810MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-145-5pMIMAT00004371hsa-miR-145{Western blot}{overexpression}19996288
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25964555MATERIALS AND METHODS: Multiplex Ligation-dependent Probe Amplification, TP53 sequencing, real-time polymerase chain reaction (PCR) for MUC1 and SCGB2A2 and immunocytochemistry, together with senescence detection assay and real-time microscopic observations were used to analyze primary neoplastic cells isolated from prostate, breast and colorectal tumors, as well as stable cancer cell lines (MCF7, MDA-MB-468, SW962, SK-MEL28, NCI-H1975 and NCI-H469)
19751512Analysis of surface markers during long term tumor culture of primary HBCEC (more than 476d) demonstrated a prominent expression of CD24, CD44 and MUC1 (CD227)
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