HCSGD entry for MSX2

1. General information

Official gene symbolMSX2
Entrez ID4488
Gene full namemsh homeobox 2
Other gene symbolsCRS2 FPP HOX8 MSH PFM PFM1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0001649Osteoblast differentiationISSbiological_process
GO:0002063Chondrocyte developmentIEAbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0003148Outflow tract septum morphogenesisIEAbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationIEAbiological_process
GO:0003416Endochondral bone growthIEAbiological_process
GO:0003712Transcription cofactor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0032792Negative regulation of CREB transcription factor activityIEAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035313Wound healing, spreading of epidermal cellsIEAbiological_process
GO:0035880Embryonic nail plate morphogenesisIEAbiological_process
GO:0042640AnagenIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045617Negative regulation of keratinocyte differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0051795Positive regulation of catagenIEAbiological_process
GO:0060346Bone trabecula formationIEAbiological_process
GO:0060363Cranial suture morphogenesisTASbiological_process
GO:0060364Frontal suture morphogenesisIEAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0061312BMP signaling pathway involved in heart developmentIEAbiological_process
GO:0070166Enamel mineralizationIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071392Cellular response to estradiol stimulusIEAbiological_process
GO:0090427Activation of meiosisIEAbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingISSbiological_process
GO:2001055Positive regulation of mesenchymal cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06601917480.95667070020.55368378981.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1708135731
GSE13712_SHEARUp0.1795902263
GSE13712_STATICDown-0.0359940387
GSE19018Up0.0206517530
GSE19899_A1Up0.0160942692
GSE19899_A2Up0.6346665262
PubMed_21979375_A1Up0.3036278361
PubMed_21979375_A2Up0.9158688198
GSE35957Up0.0139173764
GSE36640Up0.9204687737
GSE54402Down-0.2105835469
GSE9593Up0.0501902932
GSE43922Up0.0825025603
GSE24585Up0.1650849435
GSE37065Down-0.2821346268
GSE28863_A1Down-0.0741298341
GSE28863_A2Up0.4042394398
GSE28863_A3Up0.2925303987
GSE28863_A4Down-0.0094913721
GSE48662Up0.0655585659

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.