HCSGD entry for MSX2

1. General information

Official gene symbolMSX2
Entrez ID4488
Gene full namemsh homeobox 2
Other gene symbolsCRS2 FPP HOX8 MSH PFM PFM1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0001649Osteoblast differentiationISSbiological_process
GO:0002063Chondrocyte developmentIEAbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0003148Outflow tract septum morphogenesisIEAbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationIEAbiological_process
GO:0003416Endochondral bone growthIEAbiological_process
GO:0003712Transcription cofactor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0032792Negative regulation of CREB transcription factor activityIEAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035313Wound healing, spreading of epidermal cellsIEAbiological_process
GO:0035880Embryonic nail plate morphogenesisIEAbiological_process
GO:0042640AnagenIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045617Negative regulation of keratinocyte differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0051795Positive regulation of catagenIEAbiological_process
GO:0060346Bone trabecula formationIEAbiological_process
GO:0060363Cranial suture morphogenesisTASbiological_process
GO:0060364Frontal suture morphogenesisIEAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0061312BMP signaling pathway involved in heart developmentIEAbiological_process
GO:0070166Enamel mineralizationIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071392Cellular response to estradiol stimulusIEAbiological_process
GO:0090427Activation of meiosisIEAbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingISSbiological_process
GO:2001055Positive regulation of mesenchymal cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06601917480.95667070020.55368378981.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1708135731
GSE13712_SHEARUp0.1795902263
GSE13712_STATICDown-0.0359940387
GSE19018Up0.0206517530
GSE19899_A1Up0.0160942692
GSE19899_A2Up0.6346665262
PubMed_21979375_A1Up0.3036278361
PubMed_21979375_A2Up0.9158688198
GSE35957Up0.0139173764
GSE36640Up0.9204687737
GSE54402Down-0.2105835469
GSE9593Up0.0501902932
GSE43922Up0.0825025603
GSE24585Up0.1650849435
GSE37065Down-0.2821346268
GSE28863_A1Down-0.0741298341
GSE28863_A2Up0.4042394398
GSE28863_A3Up0.2925303987
GSE28863_A4Down-0.0094913721
GSE48662Up0.0655585659

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.