HCSGD entry for MSX1

1. General information

Official gene symbolMSX1
Entrez ID4487
Gene full namemsh homeobox 1
Other gene symbolsECTD3 HOX7 HYD1 STHAG1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000902Cell morphogenesisIDAbiological_process
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationIEAbiological_process
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0007517Muscle organ developmentIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0010463Mesenchymal cell proliferationIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030262Apoptotic nuclear changesIDAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0030901Midbrain developmentIEAbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035880Embryonic nail plate morphogenesisIMPbiological_process
GO:0042474Middle ear morphogenesisIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIMPbiological_process
GO:0042481Regulation of odontogenesisIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043517Positive regulation of DNA damage response, signal transduction by p53 class mediatorICbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0050821Protein stabilizationIDAbiological_process
GO:0051154Negative regulation of striated muscle cell differentiationIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060325Face morphogenesisIMPbiological_process
GO:0060349Bone morphogenesisIEAbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0061180Mammary gland epithelium developmentIEAbiological_process
GO:0061312BMP signaling pathway involved in heart developmentIEAbiological_process
GO:0071316Cellular response to nicotineIEAbiological_process
GO:0090427Activation of meiosisIEAbiological_process
GO:1902255Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIDAbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIEAbiological_process
GO:2001055Positive regulation of mesenchymal cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01597802520.87382562590.31244992571.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3351038204
GSE13712_SHEARDown-0.3729107525
GSE13712_STATICDown-0.3902812361
GSE19018Up0.3951556421
GSE19899_A1Up0.2035065451
GSE19899_A2Up1.2191771485
PubMed_21979375_A1Up1.7222316537
PubMed_21979375_A2Up1.1640181236
GSE35957Down-0.4007506425
GSE36640Up0.9302047475
GSE54402Up1.0201780687
GSE9593Down-0.2689363163
GSE43922Up0.1335200945
GSE24585Down-0.0852881441
GSE37065Down-0.0967742795
GSE28863_A1Up0.0010885820
GSE28863_A2Down-0.0405157486
GSE28863_A3Up0.2609930301
GSE28863_A4Down-0.0567263629
GSE48662Up0.0783212856

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21562774The iPSC clones could differentiate to cells originated from all three germ-cell layers, as shown by RT-PCR, for messenger RNA (mRNA) expression of alpha-fetoprotein (endoderm), MSX1 (mesoderm) and microtubule-associated protein 2 (ectoderm), and by immunostaining for alpha-fetoprotein (endoderm), alpha-smooth muscle actin (mesoderm), and beta-III-tubulin (ectoderm)
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