HCSGD entry for MSX1

1. General information

Official gene symbolMSX1
Entrez ID4487
Gene full namemsh homeobox 1
Other gene symbolsECTD3 HOX7 HYD1 STHAG1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000902Cell morphogenesisIDAbiological_process
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationIEAbiological_process
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0007517Muscle organ developmentIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0010463Mesenchymal cell proliferationIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030262Apoptotic nuclear changesIDAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0030901Midbrain developmentIEAbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035880Embryonic nail plate morphogenesisIMPbiological_process
GO:0042474Middle ear morphogenesisIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIMPbiological_process
GO:0042481Regulation of odontogenesisIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043517Positive regulation of DNA damage response, signal transduction by p53 class mediatorICbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0050821Protein stabilizationIDAbiological_process
GO:0051154Negative regulation of striated muscle cell differentiationIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060325Face morphogenesisIMPbiological_process
GO:0060349Bone morphogenesisIEAbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0061180Mammary gland epithelium developmentIEAbiological_process
GO:0061312BMP signaling pathway involved in heart developmentIEAbiological_process
GO:0071316Cellular response to nicotineIEAbiological_process
GO:0090427Activation of meiosisIEAbiological_process
GO:1902255Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIDAbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIEAbiological_process
GO:2001055Positive regulation of mesenchymal cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01597802520.87382562590.31244992571.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3351038204
GSE13712_SHEARDown-0.3729107525
GSE13712_STATICDown-0.3902812361
GSE19018Up0.3951556421
GSE19899_A1Up0.2035065451
GSE19899_A2Up1.2191771485
PubMed_21979375_A1Up1.7222316537
PubMed_21979375_A2Up1.1640181236
GSE35957Down-0.4007506425
GSE36640Up0.9302047475
GSE54402Up1.0201780687
GSE9593Down-0.2689363163
GSE43922Up0.1335200945
GSE24585Down-0.0852881441
GSE37065Down-0.0967742795
GSE28863_A1Up0.0010885820
GSE28863_A2Down-0.0405157486
GSE28863_A3Up0.2609930301
GSE28863_A4Down-0.0567263629
GSE48662Up0.0783212856

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21562774The iPSC clones could differentiate to cells originated from all three germ-cell layers, as shown by RT-PCR, for messenger RNA (mRNA) expression of alpha-fetoprotein (endoderm), MSX1 (mesoderm) and microtubule-associated protein 2 (ectoderm), and by immunostaining for alpha-fetoprotein (endoderm), alpha-smooth muscle actin (mesoderm), and beta-III-tubulin (ectoderm)
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