HCSGD entry for MSH3
1. General information
| Official gene symbol | MSH3 |
|---|---|
| Entrez ID | 4437 |
| Gene full name | mutS homolog 3 (E. coli) |
| Other gene symbols | DUP MRP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000228 | Nuclear chromosome | IBA | cellular_component |
| GO:0000403 | Y-form DNA binding | IBA | molecular_function |
| GO:0000404 | Loop DNA binding | IBA | molecular_function |
| GO:0000406 | Double-strand/single-strand DNA junction binding | IBA | molecular_function |
| GO:0000710 | Meiotic mismatch repair | IBA | biological_process |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IBA | biological_process |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0006298 | Mismatch repair | IMP | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | IBA | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IBA | molecular_function |
| GO:0016447 | Somatic recombination of immunoglobulin gene segments | IBA | biological_process |
| GO:0019237 | Centromeric DNA binding | IEA | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030983 | Mismatched DNA binding | IDA | molecular_function |
| GO:0032137 | Guanine/thymine mispair binding | IDA | molecular_function |
| GO:0032139 | Dinucleotide insertion or deletion binding | IDA | molecular_function |
| GO:0032142 | Single guanine insertion binding | IDA | molecular_function |
| GO:0032181 | Dinucleotide repeat insertion binding | IDA | molecular_function |
| GO:0032302 | MutSbeta complex | IDA | cellular_component |
| GO:0032357 | Oxidized purine DNA binding | IDA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043570 | Maintenance of DNA repeat elements | IMP | biological_process |
| GO:0045910 | Negative regulation of DNA recombination | IDA | biological_process |
| GO:0051096 | Positive regulation of helicase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9698829756 | 0.0831010638 | 0.9999902473 | 0.5467929518 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1653954753 |
| GSE13712_SHEAR | Down | -0.0223485402 |
| GSE13712_STATIC | Down | -0.1406824134 |
| GSE19018 | Up | 0.0327315028 |
| GSE19899_A1 | Down | -0.0731769230 |
| GSE19899_A2 | Down | -0.2104437822 |
| PubMed_21979375_A1 | Down | -0.2914726911 |
| PubMed_21979375_A2 | Down | -0.0273253867 |
| GSE35957 | Down | -0.0547838807 |
| GSE36640 | Down | -0.6291279151 |
| GSE54402 | Down | -0.0245720797 |
| GSE9593 | Up | 0.1660440813 |
| GSE43922 | Down | -0.2198613482 |
| GSE24585 | Up | 0.0384630511 |
| GSE37065 | Down | -0.1616690174 |
| GSE28863_A1 | Down | -0.0623491226 |
| GSE28863_A2 | Down | -0.1492928076 |
| GSE28863_A3 | Down | -0.6277770685 |
| GSE28863_A4 | Down | -0.2331999953 |
| GSE48662 | Up | 0.2191662641 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-326 | MIMAT0000756 | MIRT004747 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 19883630 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040556 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-345-5p | MIMAT0000772 | MIRT042726 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
