HCSGD entry for MSH3

1. General information

Official gene symbolMSH3
Entrez ID4437
Gene full namemutS homolog 3 (E. coli)
Other gene symbolsDUP MRP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000228Nuclear chromosomeIBAcellular_component
GO:0000403Y-form DNA bindingIBAmolecular_function
GO:0000404Loop DNA bindingIBAmolecular_function
GO:0000406Double-strand/single-strand DNA junction bindingIBAmolecular_function
GO:0000710Meiotic mismatch repairIBAbiological_process
GO:0003697Single-stranded DNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006200ATP catabolic processIBAbiological_process
GO:0006281DNA repairIDAbiological_process
GO:0006298Mismatch repairIMPbiological_process
GO:0007131Reciprocal meiotic recombinationIBAbiological_process
GO:0008094DNA-dependent ATPase activityIBAmolecular_function
GO:0016447Somatic recombination of immunoglobulin gene segmentsIBAbiological_process
GO:0019237Centromeric DNA bindingIEAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0030983Mismatched DNA bindingIDAmolecular_function
GO:0032137Guanine/thymine mispair bindingIDAmolecular_function
GO:0032139Dinucleotide insertion or deletion bindingIDAmolecular_function
GO:0032142Single guanine insertion bindingIDAmolecular_function
GO:0032181Dinucleotide repeat insertion bindingIDAmolecular_function
GO:0032302MutSbeta complexIDAcellular_component
GO:0032357Oxidized purine DNA bindingIDAmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043570Maintenance of DNA repeat elementsIMPbiological_process
GO:0045910Negative regulation of DNA recombinationIDAbiological_process
GO:0051096Positive regulation of helicase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96988297560.08310106380.99999024730.5467929518

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1653954753
GSE13712_SHEARDown-0.0223485402
GSE13712_STATICDown-0.1406824134
GSE19018Up0.0327315028
GSE19899_A1Down-0.0731769230
GSE19899_A2Down-0.2104437822
PubMed_21979375_A1Down-0.2914726911
PubMed_21979375_A2Down-0.0273253867
GSE35957Down-0.0547838807
GSE36640Down-0.6291279151
GSE54402Down-0.0245720797
GSE9593Up0.1660440813
GSE43922Down-0.2198613482
GSE24585Up0.0384630511
GSE37065Down-0.1616690174
GSE28863_A1Down-0.0623491226
GSE28863_A2Down-0.1492928076
GSE28863_A3Down-0.6277770685
GSE28863_A4Down-0.2331999953
GSE48662Up0.2191662641

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-326MIMAT0000756MIRT004747Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI19883630
hsa-miR-92b-3pMIMAT0003218MIRT040556CLASHFunctional MTI (Weak)23622248
hsa-miR-345-5pMIMAT0000772MIRT042726CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.