HCSGD entry for ASNS

1. General information

Official gene symbolASNS
Entrez ID440
Gene full nameasparagine synthetase (glutamine-hydrolyzing)
Other gene symbolsTS11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001889Liver developmentIEAbiological_process
GO:0004066Asparagine synthase (glutamine-hydrolyzing) activityEXP IDA IEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006529Asparagine biosynthetic processIC IDA IEAbiological_process
GO:0006541Glutamine metabolic processIEAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0031427Response to methotrexateIEAbiological_process
GO:0032354Response to follicle-stimulating hormoneIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042149Cellular response to glucose starvationIDA IEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043200Response to amino acidIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045931Positive regulation of mitotic cell cycleIDAbiological_process
GO:0048037Cofactor bindingIEAmolecular_function
GO:0070981L-asparagine biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94743960340.00256525210.99999024730.1000296296

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9689813409
GSE13712_SHEARUp0.1432361695
GSE13712_STATICDown-0.5270027921
GSE19018Up1.1384723098
GSE19899_A1Down-0.4110427068
GSE19899_A2Down-1.0684267532
PubMed_21979375_A1Down-0.7622514302
PubMed_21979375_A2Down-1.5252062388
GSE35957Down-0.3177284026
GSE36640Down-0.8942483836
GSE54402Down-0.7116138466
GSE9593Up0.0264095046
GSE43922Down-0.2507380107
GSE24585Down-0.0462231718
GSE37065Down-0.8906726325
GSE28863_A1Down-0.0805674871
GSE28863_A2Down-0.5156961755
GSE28863_A3Down-0.0142437105
GSE28863_A4Down-0.2650139237
GSE48662Up0.0653950362

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Aspartic AcidDB00128 NUTR00016 | EXPT01823
L-Glutamic AcidDB00142 NUTR00027
Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020723ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT029495MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031665ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT040401CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047059CLASHFunctional MTI (Weak)23622248
hsa-miR-23a-3pMIMAT0000078MIRT050405CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050820CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.