HCSGD entry for ASNS

1. General information

Official gene symbolASNS
Entrez ID440
Gene full nameasparagine synthetase (glutamine-hydrolyzing)
Other gene symbolsTS11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001889Liver developmentIEAbiological_process
GO:0004066Asparagine synthase (glutamine-hydrolyzing) activityEXP IDA IEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006529Asparagine biosynthetic processIC IDA IEAbiological_process
GO:0006541Glutamine metabolic processIEAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0008652Cellular amino acid biosynthetic processTASbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0031427Response to methotrexateIEAbiological_process
GO:0032354Response to follicle-stimulating hormoneIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042149Cellular response to glucose starvationIDA IEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043200Response to amino acidIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045931Positive regulation of mitotic cell cycleIDAbiological_process
GO:0048037Cofactor bindingIEAmolecular_function
GO:0070981L-asparagine biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94743960340.00256525210.99999024730.1000296296

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9689813409
GSE13712_SHEARUp0.1432361695
GSE13712_STATICDown-0.5270027921
GSE19018Up1.1384723098
GSE19899_A1Down-0.4110427068
GSE19899_A2Down-1.0684267532
PubMed_21979375_A1Down-0.7622514302
PubMed_21979375_A2Down-1.5252062388
GSE35957Down-0.3177284026
GSE36640Down-0.8942483836
GSE54402Down-0.7116138466
GSE9593Up0.0264095046
GSE43922Down-0.2507380107
GSE24585Down-0.0462231718
GSE37065Down-0.8906726325
GSE28863_A1Down-0.0805674871
GSE28863_A2Down-0.5156961755
GSE28863_A3Down-0.0142437105
GSE28863_A4Down-0.2650139237
GSE48662Up0.0653950362

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Aspartic AcidDB00128 NUTR00016 | EXPT01823
L-Glutamic AcidDB00142 NUTR00027
Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020723ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT029495MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031665ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT040401CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047059CLASHFunctional MTI (Weak)23622248
hsa-miR-23a-3pMIMAT0000078MIRT050405CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050820CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.