HCSGD entry for MAP3K10
1. General information
| Official gene symbol | MAP3K10 |
|---|---|
| Entrez ID | 4294 |
| Gene full name | mitogen-activated protein kinase kinase kinase 10 |
| Other gene symbols | MEKK10 MLK2 MST |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | ISS | biological_process |
| GO:0003714 | Transcription corepressor activity | ISS | molecular_function |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004706 | JUN kinase kinase kinase activity | ISS | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007224 | Smoothened signaling pathway | IMP | biological_process |
| GO:0007254 | JNK cascade | TAS | biological_process |
| GO:0007256 | Activation of JNKK activity | ISS | biological_process |
| GO:0007257 | Activation of JUN kinase activity | ISS | biological_process |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | ISS | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043425 | BHLH transcription factor binding | IPI | molecular_function |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IMP | biological_process |
| GO:0043507 | Positive regulation of JUN kinase activity | IMP | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP ISS | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3509416588 | 0.8459108089 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1104978301 |
| GSE13712_SHEAR | Up | 0.0034058259 |
| GSE13712_STATIC | Up | 0.0620789157 |
| GSE19018 | Up | 0.1264150769 |
| GSE19899_A1 | Down | -0.0397609868 |
| GSE19899_A2 | Up | 0.3581004426 |
| PubMed_21979375_A1 | Up | 0.3912706516 |
| PubMed_21979375_A2 | Up | 0.1245319935 |
| GSE35957 | Up | 0.0667202765 |
| GSE36640 | Up | 0.1951634752 |
| GSE54402 | Down | -0.0500151018 |
| GSE9593 | Up | 0.1126637440 |
| GSE43922 | Up | 0.0802427465 |
| GSE24585 | Down | -0.1121359911 |
| GSE37065 | Down | -0.0220428706 |
| GSE28863_A1 | Down | -0.3202932353 |
| GSE28863_A2 | Down | -0.0816403281 |
| GSE28863_A3 | Up | 0.3582410083 |
| GSE28863_A4 | Up | 0.0003393772 |
| GSE48662 | Up | 0.4790079084 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181b-5p | MIMAT0000257 | MIRT005545 | qRT-PCR//Western blot | Functional MTI | 20596961 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT007103 | Luciferase reporter assay | Functional MTI | 23189122 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT007103 | Luciferase reporter assay | Functional MTI | 23555551 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT007103 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-484 | MIMAT0002174 | MIRT042327 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
