HCSGD entry for MAP3K10

1. General information

Official gene symbolMAP3K10
Entrez ID4294
Gene full namemitogen-activated protein kinase kinase kinase 10
Other gene symbolsMEKK10 MLK2 MST
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityISSbiological_process
GO:0003714Transcription corepressor activityISSmolecular_function
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004706JUN kinase kinase kinase activityISSmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007224Smoothened signaling pathwayIMPbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007256Activation of JNKK activityISSbiological_process
GO:0007257Activation of JUN kinase activityISSbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0043507Positive regulation of JUN kinase activityIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMP ISSbiological_process
GO:0046330Positive regulation of JNK cascadeIMPbiological_process
GO:0046777Protein autophosphorylationISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35094165880.84591080890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1104978301
GSE13712_SHEARUp0.0034058259
GSE13712_STATICUp0.0620789157
GSE19018Up0.1264150769
GSE19899_A1Down-0.0397609868
GSE19899_A2Up0.3581004426
PubMed_21979375_A1Up0.3912706516
PubMed_21979375_A2Up0.1245319935
GSE35957Up0.0667202765
GSE36640Up0.1951634752
GSE54402Down-0.0500151018
GSE9593Up0.1126637440
GSE43922Up0.0802427465
GSE24585Down-0.1121359911
GSE37065Down-0.0220428706
GSE28863_A1Down-0.3202932353
GSE28863_A2Down-0.0816403281
GSE28863_A3Up0.3582410083
GSE28863_A4Up0.0003393772
GSE48662Up0.4790079084

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181b-5pMIMAT0000257MIRT005545qRT-PCR//Western blotFunctional MTI20596961
hsa-miR-155-5pMIMAT0000646MIRT007103Luciferase reporter assayFunctional MTI23189122
hsa-miR-155-5pMIMAT0000646MIRT007103Luciferase reporter assayFunctional MTI23555551
hsa-miR-155-5pMIMAT0000646MIRT007103Reporter assay;OtherFunctional MTI20584899
hsa-miR-484MIMAT0002174MIRT042327CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.