HCSGD entry for ATXN3
1. General information
| Official gene symbol | ATXN3 |
|---|---|
| Entrez ID | 4287 |
| Gene full name | ataxin 3 |
| Other gene symbols | AT3 ATX3 JOS MJD MJD1 SCA3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000226 | Microtubule cytoskeleton organization | IMP | biological_process |
| GO:0004221 | Ubiquitin thiolesterase activity | ISS | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006515 | Misfolded or incompletely synthesized protein catabolic process | ISS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008242 | Omega peptidase activity | IEA | molecular_function |
| GO:0010810 | Regulation of cell-substrate adhesion | IMP | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0030036 | Actin cytoskeleton organization | IMP | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | ISS | molecular_function |
| GO:0035520 | Monoubiquitinated protein deubiquitination | ISS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | ISS | biological_process |
| GO:0045104 | Intermediate filament cytoskeleton organization | IMP | biological_process |
| GO:0071218 | Cellular response to misfolded protein | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4221953117 | 0.4113700809 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1104990785 |
| GSE13712_SHEAR | Down | -0.0524393370 |
| GSE13712_STATIC | Down | -0.0316617614 |
| GSE19018 | Up | 0.2188172823 |
| GSE19899_A1 | Up | 0.2579447983 |
| GSE19899_A2 | Up | 0.0184979026 |
| PubMed_21979375_A1 | Up | 0.0177308038 |
| PubMed_21979375_A2 | Up | 0.0723423349 |
| GSE35957 | Down | -0.0607593547 |
| GSE36640 | Down | -0.1854374246 |
| GSE54402 | Up | 0.0929036293 |
| GSE9593 | Down | -0.0826901056 |
| GSE43922 | Up | 0.0265481135 |
| GSE24585 | Up | 0.4652018860 |
| GSE37065 | Up | 0.0775550692 |
| GSE28863_A1 | Down | -0.0168113194 |
| GSE28863_A2 | Down | -0.7279243393 |
| GSE28863_A3 | Down | -0.0729960207 |
| GSE28863_A4 | Down | -0.1307184632 |
| GSE48662 | Up | 0.3932559479 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
