HCSGD entry for ATXN3

1. General information

Official gene symbolATXN3
Entrez ID4287
Gene full nameataxin 3
Other gene symbolsAT3 ATX3 JOS MJD MJD1 SCA3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIMPbiological_process
GO:0004221Ubiquitin thiolesterase activityISSmolecular_function
GO:0004843Ubiquitin-specific protease activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmTAScellular_component
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006515Misfolded or incompletely synthesized protein catabolic processISSbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008242Omega peptidase activityIEAmolecular_function
GO:0010810Regulation of cell-substrate adhesionIMPbiological_process
GO:0016363Nuclear matrixIEAcellular_component
GO:0030036Actin cytoskeleton organizationIMPbiological_process
GO:0031625Ubiquitin protein ligase bindingISSmolecular_function
GO:0035520Monoubiquitinated protein deubiquitinationISSbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processISSbiological_process
GO:0045104Intermediate filament cytoskeleton organizationIMPbiological_process
GO:0071218Cellular response to misfolded proteinISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42219531170.41137008090.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1104990785
GSE13712_SHEARDown-0.0524393370
GSE13712_STATICDown-0.0316617614
GSE19018Up0.2188172823
GSE19899_A1Up0.2579447983
GSE19899_A2Up0.0184979026
PubMed_21979375_A1Up0.0177308038
PubMed_21979375_A2Up0.0723423349
GSE35957Down-0.0607593547
GSE36640Down-0.1854374246
GSE54402Up0.0929036293
GSE9593Down-0.0826901056
GSE43922Up0.0265481135
GSE24585Up0.4652018860
GSE37065Up0.0775550692
GSE28863_A1Down-0.0168113194
GSE28863_A2Down-0.7279243393
GSE28863_A3Down-0.0729960207
GSE28863_A4Down-0.1307184632
GSE48662Up0.3932559479

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.