HCSGD entry for MAP3K1
1. General information
| Official gene symbol | MAP3K1 |
|---|---|
| Entrez ID | 4214 |
| Gene full name | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
| Other gene symbols | MAPKKK1 MEKK MEKK 1 MEKK1 SRXY6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | NAS | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0003382 | Epithelial cell morphogenesis | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IDA TAS | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | NAS | biological_process |
| GO:0006915 | Apoptotic process | IBA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008545 | JUN kinase kinase activity | IEA | molecular_function |
| GO:0008637 | Apoptotic mitochondrial changes | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030036 | Actin cytoskeleton organization | IBA | biological_process |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0030838 | Positive regulation of actin filament polymerization | IEA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0061029 | Eyelid development in camera-type eye | IEA | biological_process |
| GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7445213518 | 0.0360664792 | 0.9999902473 | 0.3581466717 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0083060890 |
| GSE13712_SHEAR | Up | 0.0079305758 |
| GSE13712_STATIC | Down | -0.2172745194 |
| GSE19018 | Down | -0.1254166011 |
| GSE19899_A1 | Down | -0.6295020842 |
| GSE19899_A2 | Down | -1.4397052423 |
| PubMed_21979375_A1 | Down | -0.8741235360 |
| PubMed_21979375_A2 | Down | -0.1088358574 |
| GSE35957 | Down | -0.4278968530 |
| GSE36640 | Down | -0.1935064695 |
| GSE54402 | Down | -0.5801660087 |
| GSE9593 | Down | -0.1420728439 |
| GSE43922 | Down | -0.6750843562 |
| GSE24585 | Up | 0.3682813834 |
| GSE37065 | Up | 0.0194674784 |
| GSE28863_A1 | Up | 0.1711643656 |
| GSE28863_A2 | Up | 0.9177262405 |
| GSE28863_A3 | Up | 0.3844424710 |
| GSE28863_A4 | Down | -0.1884018016 |
| GSE48662 | Up | 0.1071790482 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| AZD-8330 | DB06061 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004142 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031009 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042622 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045762 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT046560 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047383 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052565 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
