HCSGD entry for MAP3K1

1. General information

Official gene symbolMAP3K1
Entrez ID4214
Gene full namemitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Other gene symbolsMAPKKK1 MEKK MEKK 1 MEKK1 SRXY6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityNASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0003382Epithelial cell morphogenesisIEAbiological_process
GO:0004672Protein kinase activityIDA TASmolecular_function
GO:0004709MAP kinase kinase kinase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0006915Apoptotic processIBAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008545JUN kinase kinase activityIEAmolecular_function
GO:0008637Apoptotic mitochondrial changesIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030036Actin cytoskeleton organizationIBAbiological_process
GO:0030334Regulation of cell migrationIEAbiological_process
GO:0030838Positive regulation of actin filament polymerizationIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0061029Eyelid development in camera-type eyeIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74452135180.03606647920.99999024730.3581466717

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0083060890
GSE13712_SHEARUp0.0079305758
GSE13712_STATICDown-0.2172745194
GSE19018Down-0.1254166011
GSE19899_A1Down-0.6295020842
GSE19899_A2Down-1.4397052423
PubMed_21979375_A1Down-0.8741235360
PubMed_21979375_A2Down-0.1088358574
GSE35957Down-0.4278968530
GSE36640Down-0.1935064695
GSE54402Down-0.5801660087
GSE9593Down-0.1420728439
GSE43922Down-0.6750843562
GSE24585Up0.3682813834
GSE37065Up0.0194674784
GSE28863_A1Up0.1711643656
GSE28863_A2Up0.9177262405
GSE28863_A3Up0.3844424710
GSE28863_A4Down-0.1884018016
GSE48662Up0.1071790482

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AZD-8330DB06061 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004142MicroarrayFunctional MTI (Weak)16822819
hsa-miR-21-5pMIMAT0000076MIRT031009MicroarrayFunctional MTI (Weak)18591254
hsa-miR-423-3pMIMAT0001340MIRT042622CLASHFunctional MTI (Weak)23622248
hsa-miR-125a-5pMIMAT0000443MIRT045762CLASHFunctional MTI (Weak)23622248
hsa-let-7g-5pMIMAT0000414MIRT046560CLASHFunctional MTI (Weak)23622248
hsa-miR-34a-5pMIMAT0000255MIRT047383CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052565CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.