HCSGD entry for MEF2D
1. General information
| Official gene symbol | MEF2D |
|---|---|
| Entrez ID | 4209 |
| Gene full name | myocyte enhancer factor 2D |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | molecular_function |
| GO:0000981 | Sequence-specific DNA binding RNA polymerase II transcription factor activity | IDA | molecular_function |
| GO:0001649 | Osteoblast differentiation | IEA | biological_process |
| GO:0001958 | Endochondral ossification | IEA | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0007512 | Adult heart development | IEP | biological_process |
| GO:0007517 | Muscle organ development | TAS | biological_process |
| GO:0033613 | Activating transcription factor binding | IPI | molecular_function |
| GO:0035914 | Skeletal muscle cell differentiation | IEA | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0581670985 | 0.9602385776 | 0.5228880464 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2122421389 |
| GSE13712_SHEAR | Up | 0.2208890759 |
| GSE13712_STATIC | Up | 0.1455935672 |
| GSE19018 | Up | 0.2877032760 |
| GSE19899_A1 | Up | 0.0620371321 |
| GSE19899_A2 | Up | 0.4886037123 |
| PubMed_21979375_A1 | Up | 0.4679396028 |
| PubMed_21979375_A2 | Up | 0.6628750309 |
| GSE35957 | Up | 0.1469446672 |
| GSE36640 | Up | 0.2587416137 |
| GSE54402 | Up | 0.1198442356 |
| GSE9593 | Up | 0.1342072233 |
| GSE43922 | Up | 0.3844046212 |
| GSE24585 | Up | 0.2095291750 |
| GSE37065 | Up | 0.0151049692 |
| GSE28863_A1 | Up | 0.1101302336 |
| GSE28863_A2 | Up | 0.3061197930 |
| GSE28863_A3 | Up | 0.0075868273 |
| GSE28863_A4 | Down | -0.2696434987 |
| GSE48662 | Up | 0.2733716817 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-20a-5p | MIMAT0000075 | MIRT003012 | Luciferase reporter assay | Functional MTI | 19666108 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT003015 | Luciferase reporter assay | Functional MTI | 19666108 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT027395 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029852 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031251 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037248 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044549 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051353 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
