HCSGD entry for MCM7
1. General information
| Official gene symbol | MCM7 |
|---|---|
| Entrez ID | 4176 |
| Gene full name | minichromosome maintenance complex component 7 |
| Other gene symbols | CDC47 MCM2 P1.1-MCM3 P1CDC47 P85MCM PNAS146 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000785 | Chromatin | TAS | cellular_component |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003678 | DNA helicase activity | IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006268 | DNA unwinding involved in DNA replication | IEA | biological_process |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0042325 | Regulation of phosphorylation | IMP | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042555 | MCM complex | IDA IEA IMP | cellular_component |
| GO:0071364 | Cellular response to epidermal growth factor stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9397895293 | 0.0004966339 | 0.9999902473 | 0.0411066038 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4172553378 |
| GSE13712_SHEAR | Down | -0.2174532468 |
| GSE13712_STATIC | Down | -0.2673391252 |
| GSE19018 | Down | -0.2803890202 |
| GSE19899_A1 | Down | -1.4011312825 |
| GSE19899_A2 | Down | -2.7279444424 |
| PubMed_21979375_A1 | Down | -0.9917121466 |
| PubMed_21979375_A2 | Down | -2.7591840786 |
| GSE35957 | Down | -2.4552642889 |
| GSE36640 | Down | -3.3078953396 |
| GSE54402 | Down | -0.0595500868 |
| GSE9593 | Down | -1.7725149331 |
| GSE43922 | Down | -0.7104974043 |
| GSE24585 | Up | 0.0536317554 |
| GSE37065 | Down | -0.4623845459 |
| GSE28863_A1 | Up | 0.3154645837 |
| GSE28863_A2 | Up | 0.6938825282 |
| GSE28863_A3 | Up | 0.3219414060 |
| GSE28863_A4 | Down | -0.0940934024 |
| GSE48662 | Down | -0.5384270899 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016521 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016521 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022853 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023890 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025469 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-1914-5p | MIMAT0007889 | MIRT035789 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038750 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041105 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042002 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046710 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048095 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049815 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052320 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052674 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
