HCSGD entry for ARSB

1. General information

Official gene symbolARSB
Entrez ID411
Gene full namearylsulfatase B
Other gene symbolsASB G4S MPS6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003943N-acetylgalactosamine-4-sulfatase activityTASmolecular_function
GO:0004065Arylsulfatase activityIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005764LysosomeIEA TAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006687Glycosphingolipid metabolic processTASbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0007040Lysosome organizationTASbiological_process
GO:0007041Lysosomal transportTASbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0009268Response to pHIEAbiological_process
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0030204Chondroitin sulfate metabolic processTASbiological_process
GO:0030207Chondroitin sulfate catabolic processTASbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043627Response to estrogenIEAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051597Response to methylmercuryIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09969408080.71909642110.65884264931.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1854864654
GSE13712_SHEARUp0.1952513658
GSE13712_STATICUp0.0581942425
GSE19018Up0.1186483979
GSE19899_A1Up0.0749166022
GSE19899_A2Up0.8468048523
PubMed_21979375_A1Up0.0554175699
PubMed_21979375_A2Up0.3529418865
GSE35957Up0.3447754195
GSE36640Up0.2510772643
GSE54402Up0.2864257273
GSE9593Up0.0379493902
GSE43922Up0.1397415552
GSE24585Up0.1631868190
GSE37065Up0.2817344571
GSE28863_A1Down-0.9555402198
GSE28863_A2Up0.1326129833
GSE28863_A3Down-0.1913047636
GSE28863_A4Down-0.1164552495
GSE48662Up0.2574201702

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT023384MicroarrayFunctional MTI (Weak)17612493
hsa-miR-941MIMAT0004984MIRT036564CLASHFunctional MTI (Weak)23622248
hsa-miR-224-5pMIMAT0000281MIRT046570CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

522513Arylsulfatase A, beta-D-galactosidase and beta-D-glucuronidase activities were significantly lower and arylsulfatase B activity was significantly higher in senescent cells than in actively growing cells
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