HCSGD entry for ARSB
1. General information
| Official gene symbol | ARSB |
|---|---|
| Entrez ID | 411 |
| Gene full name | arylsulfatase B |
| Other gene symbols | ASB G4S MPS6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003943 | N-acetylgalactosamine-4-sulfatase activity | TAS | molecular_function |
| GO:0004065 | Arylsulfatase activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005764 | Lysosome | IEA TAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005791 | Rough endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0007040 | Lysosome organization | TAS | biological_process |
| GO:0007041 | Lysosomal transport | TAS | biological_process |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0009268 | Response to pH | IEA | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030204 | Chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0030207 | Chondroitin sulfate catabolic process | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051597 | Response to methylmercury | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0996940808 | 0.7190964211 | 0.6588426493 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1854864654 |
| GSE13712_SHEAR | Up | 0.1952513658 |
| GSE13712_STATIC | Up | 0.0581942425 |
| GSE19018 | Up | 0.1186483979 |
| GSE19899_A1 | Up | 0.0749166022 |
| GSE19899_A2 | Up | 0.8468048523 |
| PubMed_21979375_A1 | Up | 0.0554175699 |
| PubMed_21979375_A2 | Up | 0.3529418865 |
| GSE35957 | Up | 0.3447754195 |
| GSE36640 | Up | 0.2510772643 |
| GSE54402 | Up | 0.2864257273 |
| GSE9593 | Up | 0.0379493902 |
| GSE43922 | Up | 0.1397415552 |
| GSE24585 | Up | 0.1631868190 |
| GSE37065 | Up | 0.2817344571 |
| GSE28863_A1 | Down | -0.9555402198 |
| GSE28863_A2 | Up | 0.1326129833 |
| GSE28863_A3 | Down | -0.1913047636 |
| GSE28863_A4 | Down | -0.1164552495 |
| GSE48662 | Up | 0.2574201702 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023384 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-941 | MIMAT0004984 | MIRT036564 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-224-5p | MIMAT0000281 | MIRT046570 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 522513 | Arylsulfatase A, beta-D-galactosidase and beta-D-glucuronidase activities were significantly lower and arylsulfatase B activity was significantly higher in senescent cells than in actively growing cells |
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