HCSGD entry for LRP1
1. General information
| Official gene symbol | LRP1 |
|---|---|
| Entrez ID | 4035 |
| Gene full name | low density lipoprotein receptor-related protein 1 |
| Other gene symbols | A2MR APOER APR CD91 IGFBP3R LRP LRP1A TGFBR5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0002020 | Protease binding | IEA | molecular_function |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005768 | Endosome | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | ISS | cellular_component |
| GO:0005905 | Coated pit | IEA | cellular_component |
| GO:0006898 | Receptor-mediated endocytosis | IEA | biological_process |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0010875 | Positive regulation of cholesterol efflux | ISS | biological_process |
| GO:0014912 | Negative regulation of smooth muscle cell migration | ISS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030136 | Clathrin-coated vesicle | IEA | cellular_component |
| GO:0030178 | Negative regulation of Wnt signaling pathway | ISS | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0030666 | Endocytic vesicle membrane | TAS | cellular_component |
| GO:0032370 | Positive regulation of lipid transport | ISS | biological_process |
| GO:0032374 | Regulation of cholesterol transport | ISS | biological_process |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0032429 | Regulation of phospholipase A2 activity | ISS | biological_process |
| GO:0032956 | Regulation of actin cytoskeleton organization | ISS | biological_process |
| GO:0034185 | Apolipoprotein binding | IDA IPI | molecular_function |
| GO:0035909 | Aorta morphogenesis | ISS | biological_process |
| GO:0042157 | Lipoprotein metabolic process | IEA | biological_process |
| GO:0042953 | Lipoprotein transport | NAS | biological_process |
| GO:0042954 | Lipoprotein transporter activity | NAS | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0043277 | Apoptotic cell clearance | ISS | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0051222 | Positive regulation of protein transport | IEA | biological_process |
| GO:0070325 | Lipoprotein particle receptor binding | IC | molecular_function |
| GO:0097242 | Beta-amyloid clearance | TAS | biological_process |
| GO:2000587 | Negative regulation of platelet-derived growth factor receptor-beta signaling pathway | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0117241328 | 0.2354738270 | 0.2720583627 | 0.9338773309 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2535255654 |
| GSE13712_SHEAR | Down | -0.1038692923 |
| GSE13712_STATIC | Down | -0.0568962546 |
| GSE19018 | Up | 0.2934461520 |
| GSE19899_A1 | Down | -0.1444481656 |
| GSE19899_A2 | Down | -0.3260524411 |
| PubMed_21979375_A1 | Down | -0.8513923869 |
| PubMed_21979375_A2 | Down | -0.1812666384 |
| GSE35957 | Up | 0.0127802008 |
| GSE36640 | Up | 0.5468727335 |
| GSE54402 | Down | -0.3801464866 |
| GSE9593 | Up | 0.2932813262 |
| GSE43922 | Down | -0.4749928123 |
| GSE24585 | Up | 0.7902787217 |
| GSE37065 | Down | -0.2554802409 |
| GSE28863_A1 | Up | 2.4850112581 |
| GSE28863_A2 | Up | 2.3353265479 |
| GSE28863_A3 | Up | 0.3741351677 |
| GSE28863_A4 | Down | -0.0492619252 |
| GSE48662 | Up | 0.7216237528 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tenecteplase | DB00031 | BTD00019 | BIOD00019 |
| Coagulation Factor IX (Recombinant) | DB00100 | BTD00038 | BIOD00038 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-338-5p | MIMAT0004701 | MIRT001161 | qRT-PCR//Luciferase reporter assay//Western blot | Non-Functional MTI | 19665999 |
| hsa-miR-545-3p | MIMAT0003165 | MIRT001162 | qRT-PCR//Luciferase reporter assay//Western blot | Non-Functional MTI | 19665999 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT001163 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19665999 |
| hsa-miR-1 | MIMAT0000416 | MIRT001359 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017720 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021326 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23801922 | In this context, SIRPalpha functions to inhibit prophagocytic signaling from Fcgamma receptors, complement receptors, and LDL receptor-related protein-1 (LRP-1), but not scavenger receptors |
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