HCSGD entry for LRP1

1. General information

Official gene symbolLRP1
Entrez ID4035
Gene full namelow density lipoprotein receptor-related protein 1
Other gene symbolsA2MR APOER APR CD91 IGFBP3R LRP LRP1A TGFBR5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0002020Protease bindingIEAmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0005509Calcium ion bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneISScellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006898Receptor-mediated endocytosisIEAbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0010875Positive regulation of cholesterol effluxISSbiological_process
GO:0014912Negative regulation of smooth muscle cell migrationISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030136Clathrin-coated vesicleIEAcellular_component
GO:0030178Negative regulation of Wnt signaling pathwayISSbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0032370Positive regulation of lipid transportISSbiological_process
GO:0032374Regulation of cholesterol transportISSbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032429Regulation of phospholipase A2 activityISSbiological_process
GO:0032956Regulation of actin cytoskeleton organizationISSbiological_process
GO:0034185Apolipoprotein bindingIDA IPImolecular_function
GO:0035909Aorta morphogenesisISSbiological_process
GO:0042157Lipoprotein metabolic processIEAbiological_process
GO:0042953Lipoprotein transportNASbiological_process
GO:0042954Lipoprotein transporter activityNASmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0043277Apoptotic cell clearanceISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0051222Positive regulation of protein transportIEAbiological_process
GO:0070325Lipoprotein particle receptor bindingICmolecular_function
GO:0097242Beta-amyloid clearanceTASbiological_process
GO:2000587Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01172413280.23547382700.27205836270.9338773309

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2535255654
GSE13712_SHEARDown-0.1038692923
GSE13712_STATICDown-0.0568962546
GSE19018Up0.2934461520
GSE19899_A1Down-0.1444481656
GSE19899_A2Down-0.3260524411
PubMed_21979375_A1Down-0.8513923869
PubMed_21979375_A2Down-0.1812666384
GSE35957Up0.0127802008
GSE36640Up0.5468727335
GSE54402Down-0.3801464866
GSE9593Up0.2932813262
GSE43922Down-0.4749928123
GSE24585Up0.7902787217
GSE37065Down-0.2554802409
GSE28863_A1Up2.4850112581
GSE28863_A2Up2.3353265479
GSE28863_A3Up0.3741351677
GSE28863_A4Down-0.0492619252
GSE48662Up0.7216237528

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TenecteplaseDB00031 BTD00019 | BIOD00019
Coagulation Factor IX (Recombinant)DB00100 BTD00038 | BIOD00038

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-338-5pMIMAT0004701MIRT001161qRT-PCR//Luciferase reporter assay//Western blotNon-Functional MTI19665999
hsa-miR-545-3pMIMAT0003165MIRT001162qRT-PCR//Luciferase reporter assay//Western blotNon-Functional MTI19665999
hsa-miR-205-5pMIMAT0000266MIRT001163qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19665999
hsa-miR-1MIMAT0000416MIRT001359pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-335-5pMIMAT0000765MIRT017720MicroarrayFunctional MTI (Weak)18185580
hsa-miR-9-5pMIMAT0000441MIRT021326MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23801922In this context, SIRPalpha functions to inhibit prophagocytic signaling from Fcgamma receptors, complement receptors, and LDL receptor-related protein-1 (LRP-1), but not scavenger receptors
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