HCSGD entry for LLGL1
1. General information
| Official gene symbol | LLGL1 |
|---|---|
| Entrez ID | 3996 |
| Gene full name | lethal giant larvae homolog 1 (Drosophila) |
| Other gene symbols | DLG4 HUGL HUGL-1 HUGL1 LLGL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000137 | Golgi cis cisterna | ISS | cellular_component |
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0005097 | Rab GTPase activator activity | ISS | molecular_function |
| GO:0005198 | Structural molecule activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0006461 | Protein complex assembly | IDA | biological_process |
| GO:0006887 | Exocytosis | IEA | biological_process |
| GO:0006893 | Golgi to plasma membrane transport | ISS | biological_process |
| GO:0007409 | Axonogenesis | ISS | biological_process |
| GO:0019901 | Protein kinase binding | IDA | molecular_function |
| GO:0030424 | Axon | ISS | cellular_component |
| GO:0030864 | Cortical actin cytoskeleton | IDA | cellular_component |
| GO:0030866 | Cortical actin cytoskeleton organization | IDA | biological_process |
| GO:0031901 | Early endosome membrane | ISS | cellular_component |
| GO:0032320 | Positive regulation of Ras GTPase activity | ISS | biological_process |
| GO:0032588 | Trans-Golgi network membrane | ISS | cellular_component |
| GO:0032851 | Positive regulation of Rab GTPase activity | ISS | biological_process |
| GO:0035090 | Maintenance of apical/basal cell polarity | IEA | biological_process |
| GO:0035748 | Myelin sheath abaxonal region | IEA | cellular_component |
| GO:0043085 | Positive regulation of catalytic activity | ISS | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | ISS | biological_process |
| GO:0050790 | Regulation of catalytic activity | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9727676114 | 0.0893212758 | 0.9999902473 | 0.5667852700 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0866958315 |
| GSE13712_SHEAR | Down | -0.4476028984 |
| GSE13712_STATIC | Down | -0.3668033638 |
| GSE19018 | Up | 0.1155812720 |
| GSE19899_A1 | Up | 0.0340242492 |
| GSE19899_A2 | Down | -0.1196597968 |
| PubMed_21979375_A1 | Down | -0.4971818798 |
| PubMed_21979375_A2 | Down | -0.2221867577 |
| GSE35957 | Up | 0.1160130691 |
| GSE36640 | Down | -0.1765611970 |
| GSE54402 | Down | -0.0486671120 |
| GSE9593 | Up | 0.0850276213 |
| GSE43922 | Down | -0.1066128990 |
| GSE24585 | Down | -0.1458934640 |
| GSE37065 | Down | -0.0723485828 |
| GSE28863_A1 | Up | 0.1445237597 |
| GSE28863_A2 | Down | -0.1372815613 |
| GSE28863_A3 | Down | -0.5058764412 |
| GSE28863_A4 | Down | -0.1659190052 |
| GSE48662 | Up | 0.0313480643 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026101 | qRT-PCR | Functional MTI (Weak) | 21077158 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030531 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045222 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
