HCSGD entry for LIMK1

1. General information

Official gene symbolLIMK1
Entrez ID3984
Gene full nameLIM domain kinase 1
Other gene symbolsLIMK LIMK-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIEA NASmolecular_function
GO:0004674Protein serine/threonine kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0006468Protein phosphorylationIDA IMPbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0030036Actin cytoskeleton organizationTASbiological_process
GO:0031072Heat shock protein bindingIDAmolecular_function
GO:0032233Positive regulation of actin filament bundle assemblyIDAbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043005Neuron projectionISScellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0045773Positive regulation of axon extensionISSbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0051444Negative regulation of ubiquitin-protein ligase activityIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02634616470.93404378630.37852478171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0577818865
GSE13712_SHEARUp0.2948079546
GSE13712_STATICUp0.4153626623
GSE19018Down-0.3469043170
GSE19899_A1Up0.0318078138
GSE19899_A2Up0.5928451210
PubMed_21979375_A1Up0.7644161757
PubMed_21979375_A2Up0.2727818590
GSE35957Up0.0269669834
GSE36640Down-0.1072992814
GSE54402Up1.2084553180
GSE9593Up0.0843639857
GSE43922Up0.5896336466
GSE24585Down-0.4821211639
GSE37065Up0.0997526777
GSE28863_A1Up0.0518513917
GSE28863_A2Up0.6380752863
GSE28863_A3Up0.2837707345
GSE28863_A4Up0.0199151522
GSE48662Up0.0989776841

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DabrafenibDB08912 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106b-5pMIMAT0000680MIRT020461MicroarrayFunctional MTI (Weak)17242205
hsa-miR-346MIMAT0000773MIRT042722CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

14744771Nuclear accumulation of globular actin (G-actin) and dephosphorylated cofilin was highly significant in the senescent HDF cells, accompanied with inhibition of LIM kinase (LIMK) -1 activity
14744771Significance of these findings was strengthened additionally by the fact that nuclear actin export of young HDF cells was inhibited by the treatment with leptomycin B and mutant cofilin transfection, whose LIMK-1 phosphorylation site was lost, and the old cell phenotypes were duplicated with nuclear actin accumulation, suggesting that nuclear actin accumulation was accompanied with G1 arrest during cellular senescence
Entries Per Page
Displaying Page of