HCSGD entry for LIMK1

1. General information

Official gene symbolLIMK1
Entrez ID3984
Gene full nameLIM domain kinase 1
Other gene symbolsLIMK LIMK-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIEA NASmolecular_function
GO:0004674Protein serine/threonine kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0006468Protein phosphorylationIDA IMPbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0030036Actin cytoskeleton organizationTASbiological_process
GO:0031072Heat shock protein bindingIDAmolecular_function
GO:0032233Positive regulation of actin filament bundle assemblyIDAbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043005Neuron projectionISScellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0045773Positive regulation of axon extensionISSbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0051444Negative regulation of ubiquitin-protein ligase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02634616470.93404378630.37852478171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0577818865
GSE13712_SHEARUp0.2948079546
GSE13712_STATICUp0.4153626623
GSE19018Down-0.3469043170
GSE19899_A1Up0.0318078138
GSE19899_A2Up0.5928451210
PubMed_21979375_A1Up0.7644161757
PubMed_21979375_A2Up0.2727818590
GSE35957Up0.0269669834
GSE36640Down-0.1072992814
GSE54402Up1.2084553180
GSE9593Up0.0843639857
GSE43922Up0.5896336466
GSE24585Down-0.4821211639
GSE37065Up0.0997526777
GSE28863_A1Up0.0518513917
GSE28863_A2Up0.6380752863
GSE28863_A3Up0.2837707345
GSE28863_A4Up0.0199151522
GSE48662Up0.0989776841

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DabrafenibDB08912 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106b-5pMIMAT0000680MIRT020461MicroarrayFunctional MTI (Weak)17242205
hsa-miR-346MIMAT0000773MIRT042722CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

14744771Nuclear accumulation of globular actin (G-actin) and dephosphorylated cofilin was highly significant in the senescent HDF cells, accompanied with inhibition of LIM kinase (LIMK) -1 activity
14744771Significance of these findings was strengthened additionally by the fact that nuclear actin export of young HDF cells was inhibited by the treatment with leptomycin B and mutant cofilin transfection, whose LIMK-1 phosphorylation site was lost, and the old cell phenotypes were duplicated with nuclear actin accumulation, suggesting that nuclear actin accumulation was accompanied with G1 arrest during cellular senescence
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