HCSGD entry for ARHGAP6

1. General information

Official gene symbolARHGAP6
Entrez ID395
Gene full nameRho GTPase activating protein 6
Other gene symbolsRHOGAP6 RHOGAPX-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0005100Rho GTPase activator activityISSmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmIMPcellular_component
GO:0005829CytosolTAScellular_component
GO:0005884Actin filamentNAScellular_component
GO:0007165Signal transductionIEAbiological_process
GO:0007202Activation of phospholipase C activityIDAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007266Rho protein signal transductionNASbiological_process
GO:0009967Positive regulation of signal transductionTASbiological_process
GO:0010518Positive regulation of phospholipase activityIDAbiological_process
GO:0015629Actin cytoskeletonISScellular_component
GO:0016004Phospholipase activator activityIDAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030041Actin filament polymerizationNASbiological_process
GO:0043087Regulation of GTPase activityISSbiological_process
GO:0043274Phospholipase bindingIPImolecular_function
GO:0048041Focal adhesion assemblyIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051497Negative regulation of stress fiber assemblyIMPbiological_process
GO:0051895Negative regulation of focal adhesion assemblyIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02181577450.80987025190.35505461251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0727113766
GSE13712_SHEARDown-0.2345898944
GSE13712_STATICDown-0.2655031642
GSE19018Down-0.2980365589
GSE19899_A1Up0.6766662201
GSE19899_A2Up0.7228766935
PubMed_21979375_A1Up0.9938950325
PubMed_21979375_A2Up2.0585409149
GSE35957Up0.4183696264
GSE36640Up0.7155352698
GSE54402Down-0.2307619112
GSE9593Down-0.2369691764
GSE43922Up0.5441663921
GSE24585Up0.2523222969
GSE37065Up0.3152583597
GSE28863_A1Up0.0677805901
GSE28863_A2Down-0.1337472653
GSE28863_A3Up0.2388525771
GSE28863_A4Up0.0041693332
GSE48662Down-0.1630246452

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.