HCSGD entry for LCK

1. General information

Official gene symbolLCK
Entrez ID3932
Gene full namelymphocyte-specific protein tyrosine kinase
Other gene symbolsLSK YT16 p56lck pp58lck
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000242Pericentriolar materialIDA ISScellular_component
GO:0001772Immunological synapseIDAcellular_component
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0003823Antigen bindingIEAmolecular_function
GO:0004713Protein tyrosine kinase activityEXP IDA IEA ISS TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0004722Protein serine/threonine phosphatase activityIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006882Cellular zinc ion homeostasisIEP ISSbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDA ISSbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0016032Viral processTASbiological_process
GO:0016311DephosphorylationIDA ISSbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030097HemopoiesisNASbiological_process
GO:0030139Endocytic vesicleIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030217T cell differentiationIMP ISSbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042169SH2 domain bindingIPI ISSmolecular_function
GO:0042493Response to drugIDA ISSbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042609CD4 receptor bindingIPImolecular_function
GO:0042610CD8 receptor bindingIPImolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0043548Phosphatidylinositol 3-kinase bindingIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIDA IEA ISScellular_component
GO:0045588Positive regulation of gamma-delta T cell differentiationIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0050856Regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0050862Positive regulation of T cell receptor signaling pathwayNASbiological_process
GO:0050870Positive regulation of T cell activationIDA ISSbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051117ATPase bindingIPImolecular_function
GO:0051209Release of sequestered calcium ion into cytosolIEA ISSbiological_process
GO:0051249Regulation of lymphocyte activationNASbiological_process
GO:0070474Positive regulation of uterine smooth muscle contractionIEAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMP ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.58798199160.72879156190.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0204363955
GSE13712_SHEARDown-0.0570222177
GSE13712_STATICUp0.2474158311
GSE19018Down-0.0460852800
GSE19899_A1Up0.1003055406
GSE19899_A2Up0.0118760752
PubMed_21979375_A1Up0.0618292985
PubMed_21979375_A2Up0.0310598640
GSE35957Up0.1547353816
GSE36640Up0.0761561579
GSE54402Down-0.0167392701
GSE9593Down-0.0510369271
GSE43922Up0.0818763883
GSE24585Up0.0575483854
GSE37065Down-0.0002489127
GSE28863_A1Down-0.5310954852
GSE28863_A2Down-0.2821709791
GSE28863_A3Up0.3540908840
GSE28863_A4Up0.1437393960
GSE48662Up0.0089859370

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DasatinibDB01254 -
{4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic AcidDB01830 EXPT00856
StaurosporineDB02010 EXPT02970 | EXPT02972
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDB03023 EXPT02634
(4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic AcidDB04003 EXPT00855
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDEDB06925 -
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINEDB07146 -
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINEDB07297 -
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDB08055 -
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDB08056 -
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amineDB08057 -
PonatinibDB08901 -
NintedanibDB09079 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017673MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.