HCSGD entry for LCK

1. General information

Official gene symbolLCK
Entrez ID3932
Gene full namelymphocyte-specific protein tyrosine kinase
Other gene symbolsLSK YT16 p56lck pp58lck
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000242Pericentriolar materialIDA ISScellular_component
GO:0001772Immunological synapseIDAcellular_component
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0003823Antigen bindingIEAmolecular_function
GO:0004713Protein tyrosine kinase activityEXP IDA IEA ISS TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0004722Protein serine/threonine phosphatase activityIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006882Cellular zinc ion homeostasisIEP ISSbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDA ISSbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010043Response to zinc ionIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0016032Viral processTASbiological_process
GO:0016311DephosphorylationIDA ISSbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030097HemopoiesisNASbiological_process
GO:0030139Endocytic vesicleIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030217T cell differentiationIMP ISSbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042169SH2 domain bindingIPI ISSmolecular_function
GO:0042493Response to drugIDA ISSbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042609CD4 receptor bindingIPImolecular_function
GO:0042610CD8 receptor bindingIPImolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0043548Phosphatidylinositol 3-kinase bindingIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIDA IEA ISScellular_component
GO:0045588Positive regulation of gamma-delta T cell differentiationIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0050856Regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0050862Positive regulation of T cell receptor signaling pathwayNASbiological_process
GO:0050870Positive regulation of T cell activationIDA ISSbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051117ATPase bindingIPImolecular_function
GO:0051209Release of sequestered calcium ion into cytosolIEA ISSbiological_process
GO:0051249Regulation of lymphocyte activationNASbiological_process
GO:0070474Positive regulation of uterine smooth muscle contractionIEAbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMP ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.58798199160.72879156190.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0204363955
GSE13712_SHEARDown-0.0570222177
GSE13712_STATICUp0.2474158311
GSE19018Down-0.0460852800
GSE19899_A1Up0.1003055406
GSE19899_A2Up0.0118760752
PubMed_21979375_A1Up0.0618292985
PubMed_21979375_A2Up0.0310598640
GSE35957Up0.1547353816
GSE36640Up0.0761561579
GSE54402Down-0.0167392701
GSE9593Down-0.0510369271
GSE43922Up0.0818763883
GSE24585Up0.0575483854
GSE37065Down-0.0002489127
GSE28863_A1Down-0.5310954852
GSE28863_A2Down-0.2821709791
GSE28863_A3Up0.3540908840
GSE28863_A4Up0.1437393960
GSE48662Up0.0089859370

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DasatinibDB01254 -
{4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic AcidDB01830 EXPT00856
StaurosporineDB02010 EXPT02970 | EXPT02972
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDB03023 EXPT02634
(4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic AcidDB04003 EXPT00855
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDEDB06925 -
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINEDB07146 -
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINEDB07297 -
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDB08055 -
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDB08056 -
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amineDB08057 -
PonatinibDB08901 -
NintedanibDB09079 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017673MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.