HCSGD entry for KLKB1

1. General information

Official gene symbolKLKB1
Entrez ID3818
Gene full namekallikrein B, plasma (Fletcher factor) 1
Other gene symbolsKLK3 PPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002542Factor XII activationTASbiological_process
GO:0004252Serine-type endopeptidase activityIEAmolecular_function
GO:0004497Monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA NAS TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007596Blood coagulationIEA TASbiological_process
GO:0007597Blood coagulation, intrinsic pathwayTASbiological_process
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031638Zymogen activationTASbiological_process
GO:0031639Plasminogen activationIDAbiological_process
GO:0042730FibrinolysisIEAbiological_process
GO:0051919Positive regulation of fibrinolysisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61516360700.74745452680.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0946296208
GSE13712_SHEARUp0.0021927547
GSE13712_STATICUp0.1595937708
GSE19018Down-0.0676086593
GSE19899_A1Down-0.1800312522
GSE19899_A2Up0.1755968447
PubMed_21979375_A1Down-0.0740606016
PubMed_21979375_A2Down-0.0326277911
GSE35957Up0.0024006943
GSE36640Up0.1966335226
GSE54402Down-0.1505762158
GSE9593Up0.0179462837
GSE43922Up0.1345783478
GSE24585Up0.0345560865
GSE37065Up0.3703309856
GSE28863_A1Down-0.0177479544
GSE28863_A2Up0.0668158255
GSE28863_A3Down-0.0353955018
GSE28863_A4Up0.0198931688
GSE48662Up0.0361576796

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EcallantideDB05311 -
C1 Esterase Inhibitor (Recombinant)DB09228 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.