HCSGD entry for KLKB1

1. General information

Official gene symbolKLKB1
Entrez ID3818
Gene full namekallikrein B, plasma (Fletcher factor) 1
Other gene symbolsKLK3 PPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002542Factor XII activationTASbiological_process
GO:0004252Serine-type endopeptidase activityIEAmolecular_function
GO:0004497Monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA NAS TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007596Blood coagulationIEA TASbiological_process
GO:0007597Blood coagulation, intrinsic pathwayTASbiological_process
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031638Zymogen activationTASbiological_process
GO:0031639Plasminogen activationIDAbiological_process
GO:0042730FibrinolysisIEAbiological_process
GO:0051919Positive regulation of fibrinolysisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61516360700.74745452680.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0946296208
GSE13712_SHEARUp0.0021927547
GSE13712_STATICUp0.1595937708
GSE19018Down-0.0676086593
GSE19899_A1Down-0.1800312522
GSE19899_A2Up0.1755968447
PubMed_21979375_A1Down-0.0740606016
PubMed_21979375_A2Down-0.0326277911
GSE35957Up0.0024006943
GSE36640Up0.1966335226
GSE54402Down-0.1505762158
GSE9593Up0.0179462837
GSE43922Up0.1345783478
GSE24585Up0.0345560865
GSE37065Up0.3703309856
GSE28863_A1Down-0.0177479544
GSE28863_A2Up0.0668158255
GSE28863_A3Down-0.0353955018
GSE28863_A4Up0.0198931688
GSE48662Up0.0361576796

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EcallantideDB05311 -
C1 Esterase Inhibitor (Recombinant)DB09228 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.