HCSGD entry for KCNN2

1. General information

Official gene symbolKCNN2
Entrez ID3781
Gene full namepotassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Other gene symbolsKCa2.2 SK2 SKCA2 SKCa 2 hSK2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006813Potassium ion transportNASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0015269Calcium-activated potassium channel activityIDAmolecular_function
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0016286Small conductance calcium-activated potassium channel activityIEA TASmolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0051393Alpha-actinin bindingIPImolecular_function
GO:0071805Potassium ion transmembrane transportIDAbiological_process
GO:1901379Regulation of potassium ion transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09362808020.07211278070.64109903750.5056154768

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0476664694
GSE13712_SHEARDown-0.1313605683
GSE13712_STATICUp0.0310225830
GSE19018Up1.0903262980
GSE19899_A1Down-0.6695653793
GSE19899_A2Down-0.9138190461
PubMed_21979375_A1Down-2.7467708195
PubMed_21979375_A2Down-1.1994158551
GSE35957Up0.3051285785
GSE36640Up3.5965149410
GSE54402Up0.5775846862
GSE9593Down-0.0085464209
GSE43922Down-1.4115321304
GSE24585Up0.0329657268
GSE37065Up0.0299903086
GSE28863_A1Down-0.0567710559
GSE28863_A2Up0.0345802066
GSE28863_A3Up0.2786658607
GSE28863_A4Up0.0094187629
GSE48662Down-0.0358065050

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MiconazoleDB01110 APRD01115

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029340MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.