HCSGD entry for KCNN2

1. General information

Official gene symbolKCNN2
Entrez ID3781
Gene full namepotassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Other gene symbolsKCa2.2 SK2 SKCA2 SKCa 2 hSK2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006813Potassium ion transportNASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0015269Calcium-activated potassium channel activityIDAmolecular_function
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0016286Small conductance calcium-activated potassium channel activityIEA TASmolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0051393Alpha-actinin bindingIPImolecular_function
GO:0071805Potassium ion transmembrane transportIDAbiological_process
GO:1901379Regulation of potassium ion transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09362808020.07211278070.64109903750.5056154768

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0476664694
GSE13712_SHEARDown-0.1313605683
GSE13712_STATICUp0.0310225830
GSE19018Up1.0903262980
GSE19899_A1Down-0.6695653793
GSE19899_A2Down-0.9138190461
PubMed_21979375_A1Down-2.7467708195
PubMed_21979375_A2Down-1.1994158551
GSE35957Up0.3051285785
GSE36640Up3.5965149410
GSE54402Up0.5775846862
GSE9593Down-0.0085464209
GSE43922Down-1.4115321304
GSE24585Up0.0329657268
GSE37065Up0.0299903086
GSE28863_A1Down-0.0567710559
GSE28863_A2Up0.0345802066
GSE28863_A3Up0.2786658607
GSE28863_A4Up0.0094187629
GSE48662Down-0.0358065050

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MiconazoleDB01110 APRD01115

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029340MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.