HCSGD entry for JUND

1. General information

Official gene symbolJUND
Entrez ID3727
Gene full namejun D proto-oncogene
Other gene symbolsAP-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000785ChromatinTAScellular_component
GO:0002076Osteoblast developmentIEAbiological_process
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingIEAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0071277Cellular response to calcium ionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30565391130.23231006040.99999024730.9281471008

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1517819697
GSE13712_SHEARUp0.3883371043
GSE13712_STATICDown-0.0085702582
GSE19018Up0.2322393904
GSE19899_A1Up0.0027332206
GSE19899_A2Up0.7356352471
PubMed_21979375_A1Up0.1724972743
PubMed_21979375_A2Up0.0439111406
GSE35957Down-0.0326587277
GSE36640Down-0.0828447739
GSE54402Up0.0476956694
GSE9593Up0.1443388315
GSE43922Up0.0294174759
GSE24585Up0.0810928638
GSE37065Up0.3198924052
GSE28863_A1Down-0.1376492538
GSE28863_A2Down-0.8012780451
GSE28863_A3Down-0.5936977179
GSE28863_A4Down-0.2255430384
GSE48662Up0.4046555733

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-663aMIMAT0003326MIRT005354Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20622002
hsa-miR-335-5pMIMAT0000765MIRT017287MicroarrayFunctional MTI (Weak)18185580
hsa-miR-186-5pMIMAT0000456MIRT045282CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21507983In contrast, a high incidence of apoptosis was caused by the downregulation of JunD, suggesting that it is required for the survival of v-Src-transformed CEF
21507983Levels of the p53 tumor suppressor were elevated under conditions of JunD inhibition
20300111Embryos expressing JunD in place of Jun (Jun(d/d)) can develop to term with normal fetal livers, but display cardiac defects as observed in fetuses lacking Jun
20300111Jun(d/d) mouse embryonic fibroblasts (MEFs) exhibit early senescence, which can be rescued by EGF and HB-EGF stimulation, probably through activation of Akt signaling
20300111Thus, JunD cannot functionally replace Jun in regulating fibroblast proliferation
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