HCSGD entry for JUND

1. General information

Official gene symbolJUND
Entrez ID3727
Gene full namejun D proto-oncogene
Other gene symbolsAP-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000785ChromatinTAScellular_component
GO:0002076Osteoblast developmentIEAbiological_process
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingIEAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0071277Cellular response to calcium ionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30565391130.23231006040.99999024730.9281471008

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1517819697
GSE13712_SHEARUp0.3883371043
GSE13712_STATICDown-0.0085702582
GSE19018Up0.2322393904
GSE19899_A1Up0.0027332206
GSE19899_A2Up0.7356352471
PubMed_21979375_A1Up0.1724972743
PubMed_21979375_A2Up0.0439111406
GSE35957Down-0.0326587277
GSE36640Down-0.0828447739
GSE54402Up0.0476956694
GSE9593Up0.1443388315
GSE43922Up0.0294174759
GSE24585Up0.0810928638
GSE37065Up0.3198924052
GSE28863_A1Down-0.1376492538
GSE28863_A2Down-0.8012780451
GSE28863_A3Down-0.5936977179
GSE28863_A4Down-0.2255430384
GSE48662Up0.4046555733

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-663aMIMAT0003326MIRT005354Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20622002
hsa-miR-335-5pMIMAT0000765MIRT017287MicroarrayFunctional MTI (Weak)18185580
hsa-miR-186-5pMIMAT0000456MIRT045282CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21507983In contrast, a high incidence of apoptosis was caused by the downregulation of JunD, suggesting that it is required for the survival of v-Src-transformed CEF
21507983Levels of the p53 tumor suppressor were elevated under conditions of JunD inhibition
20300111Embryos expressing JunD in place of Jun (Jun(d/d)) can develop to term with normal fetal livers, but display cardiac defects as observed in fetuses lacking Jun
20300111Jun(d/d) mouse embryonic fibroblasts (MEFs) exhibit early senescence, which can be rescued by EGF and HB-EGF stimulation, probably through activation of Akt signaling
20300111Thus, JunD cannot functionally replace Jun in regulating fibroblast proliferation
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