HCSGD entry for ITGB3

1. General information

Official gene symbolITGB3
Entrez ID3690
Gene full nameintegrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Other gene symbolsBDPLT16 BDPLT2 CD61 GP3A GPIIIa GT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationTASbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIMPbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0003756Protein disulfide isomerase activityIDAmolecular_function
GO:0004872Receptor activityIEAmolecular_function
GO:0005161Platelet-derived growth factor receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0006457Protein foldingIDAbiological_process
GO:0007044Cell-substrate junction assemblyIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007160Cell-matrix adhesionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEA TASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0008305Integrin complexIDA IEAcellular_component
GO:0010595Positive regulation of endothelial cell migrationIMPbiological_process
GO:0010745Negative regulation of macrophage derived foam cell differentiationIMPbiological_process
GO:0010888Negative regulation of lipid storageIMPbiological_process
GO:0014909Smooth muscle cell migrationIMPbiological_process
GO:0016032Viral processIEAbiological_process
GO:0030168Platelet activationIMP TASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030334Regulation of cell migrationIEAbiological_process
GO:0030949Positive regulation of vascular endothelial growth factor receptor signaling pathwayTASbiological_process
GO:0031092Platelet alpha granule membraneTAScellular_component
GO:0031258Lamellipodium membraneIEAcellular_component
GO:0032147Activation of protein kinase activityIMPbiological_process
GO:0032369Negative regulation of lipid transportIMPbiological_process
GO:0035295Tube developmentTASbiological_process
GO:0042060Wound healingICbiological_process
GO:0042470MelanosomeIDAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0043184Vascular endothelial growth factor receptor 2 bindingIPI TASmolecular_function
GO:0043235Receptor complexIDAcellular_component
GO:0045124Regulation of bone resorptionTASbiological_process
GO:0045715Negative regulation of low-density lipoprotein particle receptor biosynthetic processIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0050748Negative regulation of lipoprotein metabolic processIMPbiological_process
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0050900Leukocyte migrationTASbiological_process
GO:0060055Angiogenesis involved in wound healingIEA TASbiological_process
GO:0070527Platelet aggregationIEA IMPbiological_process
GO:0071062Alphav-beta3 integrin-vitronectin complexTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00595314390.91488907340.20349701301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1990402650
GSE13712_SHEARUp0.5631560475
GSE13712_STATICUp0.0512899570
GSE19018Up0.0020801428
GSE19899_A1Up0.1225906237
GSE19899_A2Up0.3936058001
PubMed_21979375_A1Up0.6189674330
PubMed_21979375_A2Up0.4022775214
GSE35957Down-0.3857824593
GSE36640Up0.0158517838
GSE54402Up0.6607691926
GSE9593Up0.1583281947
GSE43922Up2.1162437036
GSE24585Up1.0118423320
GSE37065Up0.6314587498
GSE28863_A1Up0.4419585437
GSE28863_A2Up1.1507836518
GSE28863_A3Down-0.1971476479
GSE28863_A4Down-0.2422834011
GSE48662Down-0.0483002649

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AbciximabDB00054 BTD00041 | BIOD00041
EptifibatideDB00063 BTD00063 | BIOD00063
Anti-thymocyte Globulin (Rabbit)DB00098 BTD00040 | BIOD00040
TirofibanDB00775 APRD00304
LefradafibanDB04863 -
LM-609DB05787 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7a-5pMIMAT0000062MIRT000708qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18679415
hsa-miR-204-5pMIMAT0000265MIRT005833MicroarrayFunctional MTI (Weak)21282569
hsa-miR-30c-5pMIMAT0000244MIRT007133qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-98-5pMIMAT0000096MIRT048710CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7a-5pMIMAT0000062NAhsa-let-7a18679415
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.