HCSGD entry for ITGB3
1. General information
Official gene symbol | ITGB3 |
---|---|
Entrez ID | 3690 |
Gene full name | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
Other gene symbols | BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001934 | Positive regulation of protein phosphorylation | TAS | biological_process |
GO:0001938 | Positive regulation of endothelial cell proliferation | IMP | biological_process |
GO:0002576 | Platelet degranulation | TAS | biological_process |
GO:0003756 | Protein disulfide isomerase activity | IDA | molecular_function |
GO:0004872 | Receptor activity | IEA | molecular_function |
GO:0005161 | Platelet-derived growth factor receptor binding | TAS | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005634 | Nucleus | IDA | cellular_component |
GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
GO:0005925 | Focal adhesion | IEA | cellular_component |
GO:0006457 | Protein folding | IDA | biological_process |
GO:0007044 | Cell-substrate junction assembly | IEA | biological_process |
GO:0007155 | Cell adhesion | TAS | biological_process |
GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
GO:0007229 | Integrin-mediated signaling pathway | IEA TAS | biological_process |
GO:0007411 | Axon guidance | TAS | biological_process |
GO:0007596 | Blood coagulation | TAS | biological_process |
GO:0008152 | Metabolic process | IDA | biological_process |
GO:0008305 | Integrin complex | IDA IEA | cellular_component |
GO:0010595 | Positive regulation of endothelial cell migration | IMP | biological_process |
GO:0010745 | Negative regulation of macrophage derived foam cell differentiation | IMP | biological_process |
GO:0010888 | Negative regulation of lipid storage | IMP | biological_process |
GO:0014909 | Smooth muscle cell migration | IMP | biological_process |
GO:0016032 | Viral process | IEA | biological_process |
GO:0030168 | Platelet activation | IMP TAS | biological_process |
GO:0030198 | Extracellular matrix organization | TAS | biological_process |
GO:0030334 | Regulation of cell migration | IEA | biological_process |
GO:0030949 | Positive regulation of vascular endothelial growth factor receptor signaling pathway | TAS | biological_process |
GO:0031092 | Platelet alpha granule membrane | TAS | cellular_component |
GO:0031258 | Lamellipodium membrane | IEA | cellular_component |
GO:0032147 | Activation of protein kinase activity | IMP | biological_process |
GO:0032369 | Negative regulation of lipid transport | IMP | biological_process |
GO:0035295 | Tube development | TAS | biological_process |
GO:0042060 | Wound healing | IC | biological_process |
GO:0042470 | Melanosome | IDA | cellular_component |
GO:0042802 | Identical protein binding | IPI | molecular_function |
GO:0043184 | Vascular endothelial growth factor receptor 2 binding | IPI TAS | molecular_function |
GO:0043235 | Receptor complex | IDA | cellular_component |
GO:0045124 | Regulation of bone resorption | TAS | biological_process |
GO:0045715 | Negative regulation of low-density lipoprotein particle receptor biosynthetic process | IMP | biological_process |
GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IMP | biological_process |
GO:0050748 | Negative regulation of lipoprotein metabolic process | IMP | biological_process |
GO:0050839 | Cell adhesion molecule binding | IPI | molecular_function |
GO:0050900 | Leukocyte migration | TAS | biological_process |
GO:0060055 | Angiogenesis involved in wound healing | IEA TAS | biological_process |
GO:0070527 | Platelet aggregation | IEA IMP | biological_process |
GO:0071062 | Alphav-beta3 integrin-vitronectin complex | TAS | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.0059531439 | 0.9148890734 | 0.2034970130 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.1990402650 |
GSE13712_SHEAR | Up | 0.5631560475 |
GSE13712_STATIC | Up | 0.0512899570 |
GSE19018 | Up | 0.0020801428 |
GSE19899_A1 | Up | 0.1225906237 |
GSE19899_A2 | Up | 0.3936058001 |
PubMed_21979375_A1 | Up | 0.6189674330 |
PubMed_21979375_A2 | Up | 0.4022775214 |
GSE35957 | Down | -0.3857824593 |
GSE36640 | Up | 0.0158517838 |
GSE54402 | Up | 0.6607691926 |
GSE9593 | Up | 0.1583281947 |
GSE43922 | Up | 2.1162437036 |
GSE24585 | Up | 1.0118423320 |
GSE37065 | Up | 0.6314587498 |
GSE28863_A1 | Up | 0.4419585437 |
GSE28863_A2 | Up | 1.1507836518 |
GSE28863_A3 | Down | -0.1971476479 |
GSE28863_A4 | Down | -0.2422834011 |
GSE48662 | Down | -0.0483002649 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
Abciximab | DB00054 | BTD00041 | BIOD00041 |
Eptifibatide | DB00063 | BTD00063 | BIOD00063 |
Anti-thymocyte Globulin (Rabbit) | DB00098 | BTD00040 | BIOD00040 |
Tirofiban | DB00775 | APRD00304 |
Lefradafiban | DB04863 | - |
LM-609 | DB05787 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-let-7a-5p | MIMAT0000062 | MIRT000708 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 18679415 |
hsa-miR-204-5p | MIMAT0000265 | MIRT005833 | Microarray | Functional MTI (Weak) | 21282569 |
hsa-miR-30c-5p | MIMAT0000244 | MIRT007133 | qRT-PCR | Functional MTI (Weak) | 23418453 |
hsa-miR-98-5p | MIMAT0000096 | MIRT048710 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
---|---|---|---|---|---|---|---|
hsa-let-7a-5p | MIMAT0000062 | NA | hsa-let-7a | 18679415 |
Entries Per Page
Displaying Page of