HCSGD entry for ITGA2B

1. General information

Official gene symbolITGA2B
Entrez ID3674
Gene full nameintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Other gene symbolsBDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GTA HPA3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0002687Positive regulation of leukocyte migrationIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0007155Cell adhesionIEA TASbiological_process
GO:0007160Cell-matrix adhesionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008305Integrin complexIEAcellular_component
GO:0009897External side of plasma membraneIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031092Platelet alpha granule membraneTAScellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050840Extracellular matrix bindingIEAmolecular_function
GO:0070051Fibrinogen bindingIEAmolecular_function
GO:0070527Platelet aggregationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39439144410.72729114400.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0044511629
GSE13712_SHEARDown-0.0358499865
GSE13712_STATICUp0.0178772410
GSE19018Down-0.0029205189
GSE19899_A1Down-0.0572892541
GSE19899_A2Down-0.0876722768
PubMed_21979375_A1Down-0.8474802180
PubMed_21979375_A2Down-0.0827949875
GSE35957Up0.2624860429
GSE36640Down-0.1253878832
GSE54402Up0.0729641956
GSE9593Down-0.0199135589
GSE43922Up0.1577617510
GSE24585Up0.6355390439
GSE37065Down-0.0115237457
GSE28863_A1Down-0.1312946594
GSE28863_A2Down-0.0334654322
GSE28863_A3Up0.5092820354
GSE28863_A4Up0.1383421120
GSE48662Down-0.1275473375

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AbciximabDB00054 BTD00041 | BIOD00041
TirofibanDB00775 APRD00304
LefradafibanDB04863 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.