HCSGD entry for IRF5
1. General information
| Official gene symbol | IRF5 |
|---|---|
| Entrez ID | 3663 |
| Gene full name | interferon regulatory factor 5 |
| Other gene symbols | SLEB10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000975 | Regulatory region DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0032494 | Response to peptidoglycan | IDA | biological_process |
| GO:0032495 | Response to muramyl dipeptide | IDA | biological_process |
| GO:0032727 | Positive regulation of interferon-alpha production | IC | biological_process |
| GO:0032728 | Positive regulation of interferon-beta production | IC | biological_process |
| GO:0032735 | Positive regulation of interleukin-12 production | IC | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4426018540 | 0.7128591733 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0367043890 |
| GSE13712_SHEAR | Up | 0.0509845874 |
| GSE13712_STATIC | Up | 0.0621639144 |
| GSE19018 | Up | 0.0547493633 |
| GSE19899_A1 | Up | 0.1331376638 |
| GSE19899_A2 | Up | 0.0445147822 |
| PubMed_21979375_A1 | Up | 0.0659223785 |
| PubMed_21979375_A2 | Up | 0.0548184860 |
| GSE35957 | Up | 0.1680324383 |
| GSE36640 | Up | 0.1263911609 |
| GSE54402 | Up | 0.0151027932 |
| GSE9593 | Down | -0.0655726503 |
| GSE43922 | Up | 0.0130469451 |
| GSE24585 | Down | -0.2864555693 |
| GSE37065 | Down | -0.0939308500 |
| GSE28863_A1 | Down | -0.2918101622 |
| GSE28863_A2 | Down | -0.2456612105 |
| GSE28863_A3 | Up | 0.1893286009 |
| GSE28863_A4 | Up | 0.0803322800 |
| GSE48662 | Up | 1.1203990038 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-22-3p | MIMAT0000077 | MIRT007158 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23303785 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | 1 | hsa-miR-146a | {Western blot} | {overexpression by miRNA precursor transfection} | 19333922 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18505922 | Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts |
| 18505922 | Bisulfite sequencing of the promoter regions of two IFN regulatory transcription factors (IRF5 and IRF7) revealed that IRF7, but not IRF5, was epigenetically silenced by methylation of CpG islands in immortal LFS cells |
| 18505922 | We conclude that the epigenetic inactivation of the IFN pathway plays a critical role in cellular immortalization, and the reactivation of IFN-regulated genes by transcription factors IRF5 and/or IRF7 is sufficient to induce cellular senescence |
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