HCSGD entry for IRF5

1. General information

Official gene symbolIRF5
Entrez ID3663
Gene full nameinterferon regulatory factor 5
Other gene symbolsSLEB10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000975Regulatory region DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0032494Response to peptidoglycanIDAbiological_process
GO:0032495Response to muramyl dipeptideIDAbiological_process
GO:0032727Positive regulation of interferon-alpha productionICbiological_process
GO:0032728Positive regulation of interferon-beta productionICbiological_process
GO:0032735Positive regulation of interleukin-12 productionICbiological_process
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44260185400.71285917330.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0367043890
GSE13712_SHEARUp0.0509845874
GSE13712_STATICUp0.0621639144
GSE19018Up0.0547493633
GSE19899_A1Up0.1331376638
GSE19899_A2Up0.0445147822
PubMed_21979375_A1Up0.0659223785
PubMed_21979375_A2Up0.0548184860
GSE35957Up0.1680324383
GSE36640Up0.1263911609
GSE54402Up0.0151027932
GSE9593Down-0.0655726503
GSE43922Up0.0130469451
GSE24585Down-0.2864555693
GSE37065Down-0.0939308500
GSE28863_A1Down-0.2918101622
GSE28863_A2Down-0.2456612105
GSE28863_A3Up0.1893286009
GSE28863_A4Up0.0803322800
GSE48662Up1.1203990038

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT007158Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23303785
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-146a-5pMIMAT00004491hsa-miR-146a{Western blot}{overexpression by miRNA precursor transfection}19333922
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18505922Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal Li-Fraumeni fibroblasts
18505922Bisulfite sequencing of the promoter regions of two IFN regulatory transcription factors (IRF5 and IRF7) revealed that IRF7, but not IRF5, was epigenetically silenced by methylation of CpG islands in immortal LFS cells
18505922We conclude that the epigenetic inactivation of the IFN pathway plays a critical role in cellular immortalization, and the reactivation of IFN-regulated genes by transcription factors IRF5 and/or IRF7 is sufficient to induce cellular senescence
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