HCSGD entry for INPPL1

1. General information

Official gene symbolINPPL1
Entrez ID3636
Gene full nameinositol polyphosphate phosphatase-like 1
Other gene symbolsOPSMD SHIP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001958Endochondral ossificationIMPbiological_process
GO:0002376Immune system processIEAbiological_process
GO:0003779Actin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processIEA TASbiological_process
GO:0006897EndocytosisIMPbiological_process
GO:0007015Actin filament organizationIMPbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030027LamellipodiumIEAcellular_component
GO:0030175FilopodiumIEAcellular_component
GO:0032868Response to insulinIEAbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046856Phosphatidylinositol dephosphorylationIEAbiological_process
GO:0097178Ruffle assemblyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36371902280.82618527790.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1224075998
GSE13712_SHEARUp0.2136791449
GSE13712_STATICDown-0.0008790351
GSE19018Up0.0042464901
GSE19899_A1Down-0.0091045182
GSE19899_A2Down-0.2067242852
PubMed_21979375_A1Up0.3588880820
PubMed_21979375_A2Up0.0292474420
GSE35957Down-0.1680488772
GSE36640Up0.3910124561
GSE54402Down-0.0059665285
GSE9593Down-0.1548197855
GSE43922Down-0.0448084880
GSE24585Up0.2566159499
GSE37065Down-0.1398028296
GSE28863_A1Up0.2362774102
GSE28863_A2Up0.2916195035
GSE28863_A3Down-0.0053814085
GSE28863_A4Down-0.0729945113
GSE48662Up0.1739332582

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-205-5pMIMAT0000266MIRT003238Western blot//Luciferase reporter assay//Northern blot//Reporter assay;Western blot;OtherFunctional MTI19033458
hsa-miR-205-5pMIMAT0000266MIRT003238Luciferase reporter assayNon-Functional MTI20065103
hsa-miR-184MIMAT0000454MIRT004354Western blot//Luciferase reporter assay//Northern blotNon-Functional MTI19033458
hsa-miR-335-5pMIMAT0000765MIRT018943MicroarrayFunctional MTI (Weak)18185580
hsa-let-7b-5pMIMAT0000063MIRT032460ProteomicsFunctional MTI (Weak)18668040
hsa-miR-671-5pMIMAT0003880MIRT039295CLASHFunctional MTI (Weak)23622248
hsa-miR-326MIMAT0000756MIRT043623CLASHFunctional MTI (Weak)23622248
hsa-miR-27b-3pMIMAT0000419MIRT046205CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-205-5pMIMAT00002661hsa-miR-20519033458
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.