HCSGD entry for INPPL1
1. General information
| Official gene symbol | INPPL1 |
|---|---|
| Entrez ID | 3636 |
| Gene full name | inositol polyphosphate phosphatase-like 1 |
| Other gene symbols | OPSMD SHIP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001958 | Endochondral ossification | IMP | biological_process |
| GO:0002376 | Immune system process | IEA | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006006 | Glucose metabolic process | IEA | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006661 | Phosphatidylinositol biosynthetic process | IEA TAS | biological_process |
| GO:0006897 | Endocytosis | IMP | biological_process |
| GO:0007015 | Actin filament organization | IMP | biological_process |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0030175 | Filopodium | IEA | cellular_component |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0042169 | SH2 domain binding | IPI | molecular_function |
| GO:0043647 | Inositol phosphate metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046856 | Phosphatidylinositol dephosphorylation | IEA | biological_process |
| GO:0097178 | Ruffle assembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3637190228 | 0.8261852779 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1224075998 |
| GSE13712_SHEAR | Up | 0.2136791449 |
| GSE13712_STATIC | Down | -0.0008790351 |
| GSE19018 | Up | 0.0042464901 |
| GSE19899_A1 | Down | -0.0091045182 |
| GSE19899_A2 | Down | -0.2067242852 |
| PubMed_21979375_A1 | Up | 0.3588880820 |
| PubMed_21979375_A2 | Up | 0.0292474420 |
| GSE35957 | Down | -0.1680488772 |
| GSE36640 | Up | 0.3910124561 |
| GSE54402 | Down | -0.0059665285 |
| GSE9593 | Down | -0.1548197855 |
| GSE43922 | Down | -0.0448084880 |
| GSE24585 | Up | 0.2566159499 |
| GSE37065 | Down | -0.1398028296 |
| GSE28863_A1 | Up | 0.2362774102 |
| GSE28863_A2 | Up | 0.2916195035 |
| GSE28863_A3 | Down | -0.0053814085 |
| GSE28863_A4 | Down | -0.0729945113 |
| GSE48662 | Up | 0.1739332582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-205-5p | MIMAT0000266 | MIRT003238 | Western blot//Luciferase reporter assay//Northern blot//Reporter assay;Western blot;Other | Functional MTI | 19033458 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT003238 | Luciferase reporter assay | Non-Functional MTI | 20065103 |
| hsa-miR-184 | MIMAT0000454 | MIRT004354 | Western blot//Luciferase reporter assay//Northern blot | Non-Functional MTI | 19033458 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018943 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032460 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039295 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-326 | MIMAT0000756 | MIRT043623 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046205 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-205-5p | MIMAT0000266 | 1 | hsa-miR-205 | 19033458 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
