HCSGD entry for IL7

1. General information

Official gene symbolIL7
Entrez ID3574
Gene full nameinterleukin 7
Other gene symbolsIL-7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002360T cell lineage commitmentIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005139Interleukin-7 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006955Immune responseIEAbiological_process
GO:0006959Humoral immune responseTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008083Growth factor activityIEA ISSmolecular_function
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0030890Positive regulation of B cell proliferationISSbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043086Negative regulation of catalytic activityIEAbiological_process
GO:0045453Bone resorptionISSbiological_process
GO:0045582Positive regulation of T cell differentiationISSbiological_process
GO:0046622Positive regulation of organ growthIEAbiological_process
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59793070550.06266752020.99999024730.4722777269

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0028618997
GSE13712_SHEARUp0.0683232538
GSE13712_STATICUp0.0614628707
GSE19018Up0.1250137273
GSE19899_A1Up0.1699730173
GSE19899_A2Down-0.5292860647
PubMed_21979375_A1Down-0.4939438783
PubMed_21979375_A2Up0.0343286531
GSE35957Down-2.0411422860
GSE36640Down-0.0113010760
GSE54402Down-0.3767443934
GSE9593Down-0.8212558201
GSE43922Up0.0216926083
GSE24585Up0.0322630817
GSE37065Up0.5219415057
GSE28863_A1Up0.7861286745
GSE28863_A2Down-0.1298965694
GSE28863_A3Down-0.0600568708
GSE28863_A4Down-0.3329475024
GSE48662Down-0.1543164150

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018556MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022978MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024567MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026781MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26140238Following sarcoma engraftment, NHS-IL12 therapy was combined with either engineered IL-7 (FcIL-7) or IL-2 (IL-2MAB602) for continuous cytokine bioavailability
26140238NHS-IL12 strongly induced innate and adaptive antitumor immunity when combined with IL-7 or IL-2
24499954DESIGN: IL-7 induced proliferation of, and IL-7 receptor signalling in, total and naive CD4 T cells of HIV patients who had low (<350 cells/mul) or normal (>500 cells/mul) CD4 T-cell counts on ART was examined and related to markers of CD4 T-cell activation and senescence and innate immune activation
24499954Downregulation of CD127 after culture with IL-7 correlated inversely with CD4 T-cell counts and directly with Ki67 expression
24499954CONCLUSION: Defects of IL-7 signalling in HIV patients with persistent CD4 T-cell deficiency receiving ART are associated with CD4 T-cell activation and senescence
22092365METHODS: We investigated parameters of T-cell homeostasis namely the proliferation/apoptotic rate of naive and memory T cells, the T-cell senescence by telomere measurement, the recent thymic T-cell production through quantification of T-cell receptor rearrangement excision circles (TRECs), and the production of interleukin (IL)-7
22092365The TREC content of CD4(+) and CD8(+) cells was lower in patients compared with controls and was correlated with the proportion of CD45RA(+) CD4(+) and CD8(+) cells and with the levels of serum and BM IL-7, which were significantly decreased in the patients
22092365CONCLUSIONS: The aberrant T-cell expansions associated with the pathogenesis of CIN result in increased proliferation/apoptosis and possibly exhaustion of peripheral blood T cells which, in association with the inadequate compensatory thymic export of new TREC expressing T cells partially because of IL-7 deficiency, may contribute to lymphopenia in CIN
20591642Hormones such as leptin, ghrelin, insulin-like growth factor 1, IGFBP3, and cytokines, including IL-7, regulate both thymopoiesis and maintenance of naive T cells in the periphery
20038483IL-7 protects both B and T lymphocytes, but IL-2, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone also have a stimulatory effect on thymopoiesis
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